MYO5A

(redirected from myosin-Va)

MYO5A

A gene on chromosome 15q21 that belongs to the myosin gene superfamily, and is abundantly expressed n melanocytes and neurones. The myosin 5’s (V’s) to which it belongs are a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation.

Molecular pathology
MYO5A mutations are linked to Elejalde syndrome (neuroectodermal melanolysosomal disease) and Griscelli syndrome 3.
References in periodicals archive ?
Mooseker, "Myosin-Va binds to and mechanochemically couples microtubules to actin filaments," Molecular Biology of the Cell, vol.
Larson, "High affinity binding of brain myosin-Va to F-actin induced by calcium in the presence of ATP," Journal of Biological Chemistry, vol.
Rab27a is the member of the Rab family that recruits myosin-Va to melanosomes (3, 4).