MYO7A(redirected from myosin-VIIa)
Notation for the gene for unconventional myosin 7A.
MYO7AA gene on chromosome 11q13.5 that encodes a protein belonging to the myosin gene superfamily of motor proteins, which is highly expressed in the retina and cochlea. It is thought to bind to membranes that are moved relative to actin filaments. MYO7A is thought to play a role in trafficking of ribbon-synaptic vesicle complexes and renewing outer photoreceptors disks; in the inner ear, it is thought to maintain the rigidity of stereocilia during the dynamic movements of the bundle.
MYO7A’s involvement in hair-cell vesicle trafficking of aminoglycosides may explain the pathogenesis of the ototoxicity seen with aminoglycosides.