MYO5A

(redirected from myosin VA)

MYO5A

A gene on chromosome 15q21 that belongs to the myosin gene superfamily, and is abundantly expressed n melanocytes and neurones. The myosin 5’s (V’s) to which it belongs are a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation.

Molecular pathology
MYO5A mutations are linked to Elejalde syndrome (neuroectodermal melanolysosomal disease) and Griscelli syndrome 3.
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References in periodicals archive ?
Direct observation of the myosin Va recovery stroke that contributes to unidirectional stepping along actin.
Myosin Va is required for normal photoreceptor synaptic activity.
The unconventional myosin Va is an actin-based motor protein that transports intracellular cargos and can bundle actin in vitro.
Although our gene chip array determined myosin Va was consistently upregulated during BMP-2 overexpression, myosin Vb and Vc were not detected.
BMP-2 Overexpression Increases Myosin Va Expression.
siRNA-Mediated knockdown of VSMC Myosin Va Inhibits Migration.
BMP-2-mediated regulation of myosin Va may be modulated by Erk signaling with [Ca.sup.2+] involvement.
Secondly, we demonstrated BMP-2 overexpression increases the expression of myosin Va but not myosin Vb or Vc.
Myosin Va directly assembles actin into antiparallel bundles [26,27] localized at the leading edge of membrane ruffles [28].
Recombinant myosin Va can express its activity by binding calmodulin to all IQ motifs in the neck.
In melanocytes, myosin Va is recruited to melanosomes by Rab 27a (4, 5, 6).
The amino acid sequence of squid brain myosin V is similar to those of mouse and human myosin Va [2].