Stage IA disease is defined as an endometrium-confined disease with myometrial
invasion occurring in less than 50% of patients.
In the parametrium, the uterine arteries give two predominant ramifications: an ascending vessel that moves cranially and provides the myometrial
arteries, and the cervico-vaginal vessel that moves caudally.
She underwent pelvic sonography, which demonstrated a large globular uterus with myometrial
thickening and myometrial
cysts with increased hypervascularity.
(6,7) Deep myometrial
invasion is common and may lead to uterine perforation.
sensitivity to oxytocin parallels expression of oxytocin receptors such that responsiveness begins at about 20 weeks' gestation and then dramatically increases at about 30 weeks' gestation.
Both of these markers are significantly correlated with higher histologic grade, stage, lymph node metastases, myometrial
invasion, and cervical involvement in patients with EC (68).YKL-40 (Human Chitinase-3-like protein 1) is a glycoprotein that belongs to the chitinase family.
[10,11] Prostaglandins, especially prostaglandin F2-alfa and vasopressin and endothelins, stimulate myometrial
contraction which is released by endometrium during menstruation.
3) A thin myometrial
layer surrounding the gestational sac.
It represents metaplasia of Mullerian system or uterine endometrial or myometrial
stroma in differentiation towards cartilage.
After letting the patient empty bladder; total uterine, total myometrial
and endometrial measurements were obtained with a 7.0 MHz vaginal transducer (Voluson 730, GE Healthcare, USA) in a lithotomy position.
Tumor size, the depth of myometrial
invasion, tumor cell labeling of proliferation marker Ki67 (Figures 5(c)-5(d)), and the presence or absence of lymphovascular invasion were recorded as part of clinical and pathologic data.
Previous studies [11, 12] have proposed that undifferentiated cells are involved in myometrial
pathologies, and also leiomyoma onset may be the result of impaired function, proliferation, and differentiation of undifferentiated cells inside the myometrium that are under the effect of ovarian hormones [13,14].