Also, the peritubular myoid cells
exhibited irregularly shaped nuclei that were not of the characteristic elongated form (Figs.
For the first time, Dirami et al performed differential plating to enrich porcine Type A Spermatogonia to decrease Sertoli and myoid cells
Hormonal modulation of the interactions of cultured rat testicular Sertoli and peritubular myoid cells
, J Androl 14:9-16 (1993).
In the human testis, AR immunoexpression was observed in Sertoli cells, peritubular myoid cells
, Leydig cells, and periarteriolar cells, but not in germinal cells.
Reduced AR in peritubular myoid cells
results in decreased sperm output.
(46,47) This, in turn, can alter the paracrine communication between Leydig cells, myoid cells
and Sertoli cells, altering spermatogenesis.
The testes have germinal epithelium composed of two compartments: interstitial, formed by the connective tissue, blood vessels and Leydig cells, a thin peritubular cover of myoid cells
and collagenous fibers surrounding the tubules; and germinal, formed by the tubules comprising germ cells (spermatogonia, primary and secondary spermatocytes and spermatozoa) and somatic cells (Sertoli) lying on a basement membrane (Fig.
(1) Although it represents the most common testicular sex cord-stromal tumor in infancy, a literature search reveals less than 100 reported cases.1 It has been postulated that JGCT originates from primitive, pluripotential gonadal stromal cells or immature Sertoli and peritubular myoid cells
. (2) Pathologically, the tumor contains mucin-containing follicles lined by granulosa cells which stain positive for inhibin-alpha and negative for alpha fetoprotein.
In mammalian testis Spermatogenesis takes place in the seminiferous tubules which are composed of Sertoli cells (SCs) and maturing germ cells surrounded by one (rodents) or more (large animals) layer(s) of peritubular myoid cells
The indicators for diagnosis of HV-CD on histopathology include lymphoid proliferation, where the follicles are regressed or depleted of germinal center cells and have expanded mantle zones with small lymphocytes arranged concentrically in an "onion-skin" fashion, an interfollicular region variably expanded with prominent hyalinized blood vessels; expanded, often dysplastic, follicular dendritic cell networks; myoid cells
; dendritic reticulum cells; and small, mostly T lymphocytes.29,30
The neoplastic smooth muscle cells were mostly spindle-shaped, although in some areas (less than 5% of the sampled tissue; 20 blocks of tumor taken in all) the myoid cells
were epithelioid-shaped [Figure 4b].
The thymus is an anterior mediastinal lymphoid organ that is mainly composed of epithelial cells in the outer cortex, myoid cells
, and lymphocytes in the germinal center.