myoglobulin

myoglobulin

 [mi″o-glob´u-lin]
a globulin from muscle serum.

my·o·glob·u·lin

(mī'ō-glob'yū-lin),
Globulin present in muscle tissue.

my·o·glob·u·lin

(mī'ō-glob'yū-lin)
Globulin present in muscle tissue.
Mentioned in ?
References in periodicals archive ?
The most commonly used protocol for evaluating the success of methotrexate administration in treating ectopic pregnancy is the protocol with 15% BhCG decrease between Days 4 and 7, which was defined by Kirk E et al.6 In addition to monitoring BhCG levels, levels of many markers, such as creatine kinase, myoglobulin, progesterone, relaxin, cancer antigen 125 (ca 125), metalloprotease-12, and pregnancy-associated plasma protein A (PAPP-A), were studied for ectopic pregnancy monitoring and treatment success.7,8 In the study conducted by Turgut et al., it was observed that there is an increase in MPV and leukocyte counts during ectopic pregnancy.9
Hypovolemia caused by rhabdomyolysis or the direct toxic effect of myoglobulin causes acute renal failure.
Caption: FIGURE 1: The graph shows the levels of creatinine kinase (CK) and myoglobulin in the 7-axis and the admission days in the %-axis.
Days Creatinine Myoglobulin Creatinine Urea (according to kinase (normal (normal (normal admission) (normal 24-77 ng/L) 60-105 3.5-8.1 40-280 U/L) micromole/L) mmol/L) 1 -- -- 128 16.8 2 -- -- -- -- 3 -- -- -- -- 4 -- -- 119 -- 5 10865 -- 108 -- 6 10750 -- 92 -- 7 22520 -- 134 -- 8 35080 -- 134 -- 9 >20000 26300 100 22.2 10 8070 7110 85 21.8 11 3350 2590 74 19.5 12 1740 -- 74 17.0 13 755 -- 62 13.3 14 314 -- 70 10.4 15 197 143 68 8.1 16 149 89 81 7.7 17 112 94 79 8.0 22 389 -- 81 8.0 26 72 -- 85 -- 29 71 -- 85 -- TABLE 2: Screening for autoantibodies known to be associated to polymyositis, dermatomyositis, and isolated statin (HMG-CoA reductase inhibitor) causing myalgia.
Since the increase in CK was mild, values of serum and urinary myoglobulin were not measured, and, also, the two cases with elevated activity were cardiac.
Serum lactate level was found to be increased in 192 of the patients (59.1%), CK was found to be increased in 69 (21.2%), LDH and cTnT were found to be increased in 62 (19.1%), CK-MB was found to be increased in 28 (8.6%) and myoglobulin was found to be increased in 11 (3.4%) (Figure 1).
c) Diminished iron containing proteins--Many of the enzymes like cytochrome c, cytochrome oxidase and myoglobulin are reduced leading to the epithelial changes seen in IDA.
On day 16 after the patient was admitted to the hospital, results of laboratory testing showed improved values for creatine phosphokinase (1,855 ng/mL), aspartate aminotransferase (101 IU/L), alanine aminotransferase (162 IU/L), lactate dehydrogenase (294 IU/L), and urine myoglobulin (10 [micro]g/L).
The column had been calibrated with molecular mass markers, including blue dextran 2000 (to determine void volume), bovine serum albumin (67 kDa), ovalbumin (43 kDa), chymotrypsinogen A (25 kDa), myoglobulin (17.6 kDa), ribonuclease A (13.7 kDa), aprotinin (6.5 kDa) and vitamin B12 (1.3 kDa) (GE Healthcare).
If hypokalemia is not treated early, it may lead to worsening of mild myalgia to tetraplegia or severe acute renal failure because of the release of intracellular muscle constituents such as CPK and myoglobulin into the circulation (7).
aldolase (158 kDa), BSA (67 kDa), ovalbumin (43 kDa), chymotrypsinogen A (25 kDa), myoglobulin (17.6 kDa), ribonuclease A (13.7 kDa), aprotinin (6.5 Da) and vitamin B12 (1.3 kDa) (GE Healthcare), was conducted to determine the molecular mass of the protein.
Gel filtration on a fast protein liquid chromatography (FPLC)-Superdex 75 column, which had been calibrated with molecular mass markers, including Blue Dextran 2000, aldolase (158 kDa), BSA (67kDa), ovalbumin (43kDa), chymotrypsinogen A (25 kDa), myoglobulin (17.6 kDa), ribonuclease A (13.7 kDa), aprotinin (6.5 Da), and vitamin B12 (1.3 kDa) (GE Healthcare), was conducted to determine the molecular mass of the protein (Wang and Ng 2001b).