Insufficient transplacental nutrient supply for the growth of large litters may partially inhibit myogenesis
and in consequence may lead to lower daily gain of reared and fattened animals and carcass meat content (Gondret et al., 2005; Rehfeldt and Kuhn, 2006).
A systems approach reveals that the myogenesis
genome network is regulated by the transcriptional repressor RP58.
Effect of a neonatal low-protein diet on the morphology of myotubes in culture and the expression of key proteins that regulate myogenesis
in young and adult rats.
First discovered in 1994 as an immune modulating agent,1 it is considered anabolic for proteins, enhancing myogenesis
and providing protection against protein degradation.2 The release of IL-15 upon exercise also increases glucose uptake by translocating GLUT4 to the plasma membrane.
Thus the hyperplasia, of myofibers, as seen in our study could result from fiber branching with subsequent hypertrophy of new fibers or myogenesis
. It has been hypothesized and seen in earlier studies as well17.
Previous experimental studies have found that the possible pathogenesis of LGMD2A involves increased myonuclei apoptosis, impaired muscle adaption, and faulty myogenesis
IGF1 has significant biological functions including increases the stimulating myogenesis
, intake of glucose, prevents apoptosis, attend the activation of cell cycle genes, interrupts in the synthesis of DNA, protein, RNA, and in cell proliferation, enhance the synthesis of lipids and stimulating the production of progesterone in granular cells (Etherton, 2004).
Wnt signaling in myogenesis
. Trends Cell Biol., 22(11):602-9, 2012.
(2011) The myogenic kinome: protein kinases critical to mammalian skeletal myogenesis
. Skeletal Muscle 1, 1-18.
HMGA Proteins in Myogenesis
. Adipogenesis and osteogenesis, initiated by MSCs, are discussed above.
Adding chemical factors to cell culture media such as ascorbate, dexamethasone (dex), and bone morphogenetic proteins (BMPs) promotes osteogenesis; serumfree medium and transforming growth factor-[[beta].sub.1] (TGF-[[beta].sub.1]) promote chondrogenesis; growth and differentiation factor 5 (GDF-5) promotes tenogenesis; platelet derived growth factor (PDGF) promotes myogenesis
; and dex, insulin, and 3-isobutyl-1-methylxanthine (IBMX) promote adipogenesis (Figure 1) [3-5].
Muscle tissue damaged by an injected substance has the ability to perform myogenesis