shows a characteristic biphasic pattern composed of (1) myoid nodules of eosinophilic spindled cells and (2) smaller, ovoid primitive cells with scanty cytoplasm associated with thin-walled, branching blood vessels (Figure 14, A and B).
Recently, Murray et al  reported the story of a 24-year-old woman, with PDGFRB mutation, who experienced late recurrences during her pregnancy (such as a lesion of the lower lip and a myofibroma
histologically confirmed a few months later) after classical multicentric IM in infancy (skin, subcutaneous, bone and pancreatic masses) with spontaneous regression.
Because of its location on the posterior neck, our differential diagnosis included fibromatosis colli and solitary infantile myofibroma
. Histologic sampling offered a definitive diagnosis and further characterized the tumor as the spindle cell variant of RMS.
are the most common fibrous tumor affecting infants.
The overall findings were of a benign myofibroblastic proliferation consistent with myofibroma
In this case, firm fibrotic lesions to consider include myofibroma
, irritation fibroma, neurofibroma, angiofibroma, myofibromatosis, and fibrotic pyogenic granuloma.
Benign lesions include the fibrovascular polyp, myofibroma
, pedunculated lipoma, and leiomyoma; malignant lesions include adenocarcinoma from Barrett's oesophagus, squamous cell carcinoma, leiomyosarcoma, fibrosarcoma, rhabdomyosarcoma, melanoma, oat cell carcinoma, and lymphoma.
The term myopericytoma was initially proposed by Requena et al (7) as an alternative for adult solitary myofibroma
. Subsequently, Granter et al (8) expanded the term to include pericytic tumors with myoid differentiation (immunoreactive for SMA and muscle-specific actin), which showed characteristic histologic features consisting of round to oval cells with eosinophilic cytoplasm, arranged circumferentially around vascular lumina in an "onion skin"(multilayered) pattern.
of the zygomatic bone in an older child: A case report
Other lesions to be included in the histologic differential diagnosis are solitary myofibroma
, fibrous histiocytoma, desmoid tumor, and spindle cell lipoma.
(3) There are three types of infantile myofibromas
: solitary myofibroma
, multicentric fibromatosis without visceral involvement, and multicentric fibromatosis with visceral involvement.
You may hear your health care professional call fibroids by other terms, including uterine leiomyomas, fibromyomas, fibromas, myofibromas