Thus, in this study, we examined the changes in the gene regulatory network caused by knockout of the MyoD gene during myoblast
The fusion of myoblasts
is a critical step in the formation of embryonic muscle fibers as it determines muscle size, among other things.
We believe myoblast
transplantation is the right platform for damaged heart muscle repair.
Matrix metalloproteinase 13 is a new contributor to skeletal muscle regeneration and critical for myoblast
These findings suggest that miR-127-3p is probably associated with muscle development by playing roles in myoblast
proliferation and differentiation.
purity of human skeletal muscle culture was determined by immunostaining for desmin expression and cultures with purity more than 70% desmin positive cells were used for experiments.
2]induced cytotoxicity, C2C12 mouse myoblast
cells were cultured in the presence of 100 [micro]M [H.
The paper ("A Double-blind, Randomized, Controlled, Multicenter Study to Assess the Safety and Cardiovascular Effects of Skeletal Myoblast
Implantation by Catheter Delivery in Patients with Chronic Heart Failure Following Myocardial Infarction") discusses part one of the MARVEL phase II/III study, previously presented by Thomas Povsic, MD, Ph.
based biotechnology company, which has a laboratory in Worcester, reported in a news release that patients with poor heart functioning and congestive heart failure who were treated with myoblast
transplants did better after a year than patients treated with standard drugs.
Histology confirmed that myoblast
engraftment and myofiber formation occurred, but further research is needed to assess whether the transplant procedure imparts any functional improvement, the researchers said.
Among other activities, the companies will co-fund Genzyme's ongoing Myoblast
Autologous Graft in Ischemic Cardiomyopathy (MAGIC) Phase 2 clinical trial of cell therapy to repair damaged heart tissue.