In vitro myelotoxic
effects of cypermethrin and mancozeb on human hematopoietic progenitor cells.
(50,52) Previous use of myelotoxic
chemotherapy and radiotherapy to red marrow are strong predictors of hematotoxicity following PRRT.
Cases of chemotherapy (myelotoxic
) induced pancytopenia were excluded.
A known myelotoxic
agent, benzene affects erythrocytes, leukocytes and platelets, respectively causing anemia, polychromasia, basophilic stippling and peripheral erythroblasts, lymphopenia and thrombocytopenia (28).
Numerous studies conducted have shown that the frequency of each condition differs considerably depending on the differences in methodology, stringency of diagnostic criteria, period of observation, geographic area, age pattern, nutritional status, prevalence of infectious diseases, genetic differences, and varying exposure to myelotoxic
agents among other factors.
The randomised, multi-centre, double-blind, placebo-controlled phase III study investigated the safety and efficacy of a once-per-cycle dose of F-627 in women with stage II-IV breast cancer who are receiving myelotoxic
TA chemotherapy treatment (Taxotere (docetaxel + Adriamycin (doxorubicin)), with participants randomised 2:1.
There was no myelotoxic
effect or autoimmune effect on peripheral blood cells which may be due to the fact that that the tested material was not in contact with blood [13, 22] but also due to the chemical composition of the material whose biocompatibility has already been confirmed in many studies [14-21].
Valaciclovir Less myelotoxic
and chances of cytopenia are not more than placebo.
Among these side effects, the most serious one that raises the most controversy is the myelotoxic
Tacrolimus metabolite M-III may have nephrotoxic and myelotoxic
effects and increase the incidence of infections in kidney transplant recipients.
The etiology of thrombocytopenia in liver disease include portal hypertension (through hypersplenism), antibody-mediated platelet destruction (mainly in viral hepatitis), decreased thrombopoietin production by diseased liver and myelotoxic
effects of alcohol and hepatitis virus6.
In addition, the shortened platelet mean lifetime and myelotoxic
effects of alcohol or hepatitis viruses also reduced the platelet count.