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pertaining to or characterized by abnormal proliferation of bone marrow constituents.
myeloproliferative disorders a group of usually neoplastic diseases, which may be related histogenetically by a common multipotential stem cell; it includes among others acute myelogenous leukemia, chronic granulocytic leukemia, acute and chronic myelomonocytic leukemias, and polycythemia vera. An interrelationship with the lymphoproliferative disorders is thought to exist.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
myeloproliferative disordersA group of diseases featuring excessive production of blood cells by bone marrow precursors. The group includes POLYCYTHAEMIA VERA, chronic myelogenous LEUKAEMIA, platelet over-production (essential THROMBOCYTHAEMIA) and idiopathic MYELOFIBROSIS. A common feature is clonal haematopoiesis probably involving the haematopoietic stem cell. A high proportion of patients with these disorders have a mutation of the Janus kinase 2 (JAK2) gene on the short arm of chromosome 9.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005