myeloproliferative disorders


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myeloproliferative

 [mi″ĕ-lo-pro-lif´er-ah″tiv]
pertaining to or characterized by abnormal proliferation of bone marrow constituents.
myeloproliferative disorders a group of usually neoplastic diseases, which may be related histogenetically by a common multipotential stem cell; it includes among others acute myelogenous leukemia, chronic granulocytic leukemia, acute and chronic myelomonocytic leukemias, and polycythemia vera. An interrelationship with the lymphoproliferative disorders is thought to exist.

myeloproliferative disorders

A group of diseases featuring excessive production of blood cells by bone marrow precursors. The group includes POLYCYTHAEMIA VERA, chronic myelogenous LEUKAEMIA, platelet over-production (essential THROMBOCYTHAEMIA) and idiopathic MYELOFIBROSIS. A common feature is clonal haematopoiesis probably involving the haematopoietic stem cell. A high proportion of patients with these disorders have a mutation of the Janus kinase 2 (JAK2) gene on the short arm of chromosome 9.
References in periodicals archive ?
Only 1 study has provided an estimate of the frequency of the NS-related myeloproliferative disorder (NS/MPD) or monocytosis of NS [10].
Majority of patients with noncirrhotic, nonmalignant PVT have better prognosis compared to patients with cirrhosis-associated PVT and PVT associated with advanced malignancy or rapidly progressing myeloproliferative disorder. In those cases, survival is limited by underlying disease rather than PVT itself.
Scapin et al., "Heparin-induced thrombocytopenia in patients with philadelphia-negative myeloproliferative disorders and unusual splanchnic or cerebral vein thrombosis," Acta Haematologica, vol.
They most commonly arise in patients previously diagnosed with a myeloproliferative disorder, but they can be the presenting sign of cancer or even precede the onset of hematogenous disease by months to years.
ETV6-ACSL6 fusion is a rare abnormality that is associated with myeloproliferative disorders, myelodysplasia, or acute myeloid leukemia with eosinophilia or basophilia.
Myeloproliferative disorders in equines species are rarely reported (SEARCY & ORR, 1981; McCLURE et al., 0001; TAINTOR, 0010).
[USPRwire, Tue Nov 03 2015] GlobalData's clinical trial report, "Myeloproliferative Disorders Global Clinical Trials Review, H2, 2015" provides an overview of Myeloproliferative Disorders clinical trials scenario.
(2) Leukemogenic risk of Hydroxyurea is extrapolated from its reported risk in myeloproliferative disorders. (3) Hematologic Malignancies in patient with sickle cell anemia are rare.
The causes of thrombocytosis could be multiple such as myeloproliferative disorders ,reactive thrombocytosis, Post splenectomy and hyposplenism.2
Congenital leukaemia and the neonatal myeloproliferative disorders associated with Down's syndrome.
Hematologic malignancies can be categorized as myeloid neoplasms, lymphoid neoplasms (leukemias and lymphomas), and myeloproliferative disorders.
A prospective evaluation of primary myeloproliferative disorders. Gastroenterology 1988;94:1063-9.