Similar results were obtained in rat models, demonstrating that maternally administered G-CSF crosses the placenta and has myelopoietic
effects even at low concentrations in the fetus (26).
GM-CSF is basically a hematopoietic and myelopoietic
growth factor (17,18) which also promotes production of pro-inflammatory cytokines such as 'TNF-[alpha], IL-6, IL-12p70, IL-23 and IL-1[beta] as well as chemokines like CCL22, CCL24, CCL5 and CCL1 which promote leukocyte recruitment' (17).
Barnees et al., "The myelopoietic
supportive capacity of mesenchymal stromal cells is uncoupled from multipotency and is influenced by lineage determination and interference with glycosylation," Stem Cells, vol.
Histological examination confirmed the diagnosis of EMH because of the presence of hematopoietic cells differentiated into mature myelopoietic
, erythropoietic, and megakaryocytic cells (Figure 3).
Coming from a myelopoietic
origin, red blood cells mature from erythroblasts and have a high turnover rate as they are exposed to severe mechanical stress during circulation (45).
Tinhofer, "Tuning the rheostat of the myelopoietic
system via Fas and TRAIL," Critical Reviews in Immunology, vol.
Evaluation of tissue disposition, myelopoietic
and immunologic responses in mice after long-term exposure to nickel sulphate in the drinking water.
Evaluation of tissue deposition myelopoietic
and immunologic responses in mice after long term exposure to nickel sulfate in the drinking water.
and erythropoietic cells together with the lymphocytes are the major cell types.
But this suppression is a temporary event that leads to subsequent myelopoietic