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MRI may distinguish any pathological alteration within the cord as myelomalacia if there is an amplified signal on T2-weighted MRI sequences in the substance of the cord.
(b) Sagittal T2 MRI showing significantly compressing the cervicomedullary junction and the upper cervical cord with evidence of focal myelomalacia (circle)
noted that the delay between the initial injury and symptom onset can be either subacute, due to CSF leak, meningitis, or abscess, or chronic, due to myelomalacia and spinal cyst formation [12].
Diagnostic imaging features of tuberculosis radiculomyelitis: Loculation and destruction of the subarachnoid space, loss of contour of the spinal cord, myelomalacia and adhesions (thickening, clumping or matting) of the nerve roots particularly in the lumbar spine are common MRI findings of TBRM.
A possible limitation for this study included the selection of high-intensity signal changes, defined as myelomalacia, found on magnetic resonance imaging (MRI) being selected as the imaging reference standard.
Following a severe concussive injury, spinal cord damage may continue in cranial and caudal directions and results in ascending-descending diffuse myelomalacia. Following a thoracolumbar disc herniation, this may clinically be characterized by systemic signs of toxemia, a flaccid abdomen, the level of 'cut-off' of the cutaneous trunci reflex response migrating cranially, a shift from upper motor neuron to lower motor neuron signs in the rear limbs, progressive involvement of the forelimbs and eventually respiratory paralysis and death.
A well-known diagnostic challenge is differentiation of edema from myelomalacia in the setting of spondylosis and cord compression.
Large C4/5 spondylotic disc bulge resulting in spinal stenosis and myelomalacia in a Klippel-Feil patient.