myeloma

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Related to myeloma protein: plasma cell myeloma, monoclonal protein

myeloma

 [mi″ĕ-lo´mah]
1. a tumor composed of plasma cells of the type normally found in the bone marrow.
giant cell myeloma giant cell tumor (def. 1).
multiple myeloma see multiple myeloma.
plasma cell myeloma multiple myeloma.
solitary myeloma a variant of multiple myeloma in which there is a single localized tumor focus. Called also plasma cell tumor.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

my·e·lo·ma

(mī'ĕ-lō'mă),
1. A tumor composed of cells derived from hemopoietic tissues of the bone marrow.
2. A plasma cell tumor.
[myelo- + G. -oma, tumor]
Farlex Partner Medical Dictionary © Farlex 2012

myeloma

(mī′ə-lō′mə)
n. pl. myelo·mas or myelo·mata (-mə-tə)
A malignant tumor formed by the cells of the bone marrow.

my′e·lo′ma·toid′ (-toid′) adj.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

myeloma

Malignant plasmacytoma, multiple myeloma, multiple plasmacytoma of bone, myelomatosis, plasma cell myeloma Hematology A neoplastic proliferation of plasma cells in BM and extramedullary sites; if circumscribed, plasmacytoma Epidemiology MM comprises 10% of hematopoietic malignancies, causing 10,000 deaths/yr–US; ↑ with age; black:white 2:1 Clinical As the myeloma cells proliferate in BM, they cause osteolysis, resulting in pathologic fractures and industrial strength pain, anorexia, nausea, thirst, fatigue, muscle weakness, restlessness, confusion; BM replacement by neoplastic plasma cells results in ↑ infections and anemia due to displacement of normal WBCs, and erythroid series; excess Igs in circulation plug up renal tubules Lab Monoclonal Igs, often light chains, in serum, urine; ↑ Ca2+; normal PO4, normal alk phos Complications Painful pathologic fractures, anemia, hypercalcemia, renal failure, recurrent bacterial infections Treatment 1º chemotherapy: Melphalan and prednisone; VAD–vincristine, Adriamycin, dexamethasone in new cases; IFN-α has been used for maintenance; myeloablative therapy, allogeneic BMT from HLA-matched siblings. See Clear cell, myeloma, Indolent myeloma, Myeloma kidney, Solitary myeloma.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

my·e·lo·ma

(mī'ĕ-lō'mă)
1. A tumor composed of cells derived from hemopoietic tissues of the bone marrow.
2. A plasma cell tumor.
[myelo- + G. -oma, tumor]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

myeloma

A tumour derived from a lymphocyte. See LYMPHOMA, MYELOMATOSIS.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

myeloma

a cancerous tumour of the bone marrow.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Myeloma

A tumor that originates in bone marrow and usually spreads to more than one bone.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

my·e·lo·ma

(mī'ĕ-lō'mă)
1. A tumor composed of cells derived from hemopoietic tissues of bone marrow.
2. A plasma cell tumor.
[myelo- + G. -oma, tumor]
Medical Dictionary for the Dental Professions © Farlex 2012

Patient discussion about myeloma

Q. Multiple Myeloma what and how is it treated and what is MGUF

A. Were you referring by any chance to MGUS (monoclonal gammopathy of unknown significance)? It's a condition that resembles myeloma but is much more widespread and by itself isn't considered malignant. It may, however, deteriorate to multiple myeloma over the years.

Myeloma is treated with chemotherapy of various kinds, and sometimes with bone marrow transplantation with the patients own bone marrow.

You may read more here:
www.nlm.nih.gov/medlineplus/multiplemyeloma.html

More discussions about myeloma
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References in periodicals archive ?
Fc and Fab and F (ab') 2 fragments were produced from several purified human myeloma proteins of each of the IgG subclasses, by pepsin and papain digestion (16).
Balb/c mice (8-12 weeks of age) were immunized with four intraperitoneal injections of Fc fragments of human IgG 1 or IgG2 myeloma proteins emulsified in Freund's complete adjuvant (Sigma, USA) (first injection) or incomplete adjuvant (Sigma) (other injections) (50 [micro]g every 2 weeks).
Fc, Fab and F (ab') 2 fragments were prepared from several purified human myeloma proteins of each of the IgG subclasses, by pepsin and papain digestion (17).
Specificity of the MAbs was determined, using a panel of purified myeloma proteins, including IgG1 (n=9), IgG2 (n=4), IgG3 (n=7) and IgG4 (n=7) subclasses.
Specificity of these MAbs was determined, using a panel of purified myeloma proteins, including IgM, IgG, IgA, IgD, IgE, IgG1 (n=9), IgG2 (n=4), IgG3 (n=7) and IgG4 (n=6) subclasses.
7 shows dose-response curves resulting from assay of 50-[micro]L aliquots of human myeloma proteins (kappa chain).
Eight different mixtures of human myeloma proteins from each subclass were prepared in PBS solution with 5 g/L bovine serum albumin and assayed using the same protocol developed for assay of IgG3 (2-h incubation).