myeloma cast

myeloma cast

a urinary cast containing Bence Jones protein and desquamated cells of the tubular epithelium, seen with multiple myeloma in the condition known as myeloma kidney disease.
References in periodicals archive ?
Impact of free light chain haemodialysis in myeloma cast nephropathy: a case-control study.
Studies in patient with multiple myeloma and renal failure due to myeloma cast nephropathy (MYRE)
As a result, the peculiar histologic lesion of the myeloma cast nephropathy consists of a chronic tubulointerstitial nephropathy with marked tubular atrophy, laminated intratubular casts, and extensive interstitial fibrosis.
Following evidence in animal model that aciduria increases the nephrotoxicity of Bence Jones protein independently of urinary flow rate [88,89], alkalinization of the urine through oral bicarbonate has been recommended in patients with multiple myeloma and Bence Jones proteinuria to prevent or treat myeloma cast nephropathy.
5-11) There are some morphologic patterns that are readily recognizable at the light microscopic level, especially when the manifestations are florid, including that of myeloma cast nephropathy, nodular glomerulosclerosis associated with light or heavy chain deposition disease, and light and heavy chain (AL and AH) amyloidosis.
Macrophage origin of the multinucleated cells of myeloma cast nephropathy.