Bone marrow biopsy showed normocellular marrow with reduced megakaryocytes, dyserythropoiesis and dysplasia in the myeloid series
with prominent vacuolation of the myeloid precursors.
Where any suspicion in cell morphology expected then peroxide (POX) stain was used to differentiate myeloid series
pathology from lymphoid one.
Acute myelogenous leukaemia (AML) is a condition characterized by malignant transformation of blood cells belonging to myeloid series
that consists of granulocytes, monocytes, erythrocytes, and megakaryocytes.
Chronic myeloid leukemia is a pluripotential stem cell disorder characterised by anemia, markedly elevated leucocyte count with shift to left in the myeloid series
, basophilia, often thrombocytosis and splenomegaly.
The myeloid series of cells showed 52% blasts, only 5% mature lymphocytes, and 1% plasma cells [Figure 3].
The myeloid series showed 94% CD13, 82% CD33, 88% CD117, 73% CD34, and 41% HLA-DR positive.
Bone marrow aspiration from the sternum showed a hypocellular marrow with complete absence of the erythroid series, a normal myeloid series
, and megakaryocytes.
The myeloid series
was left-shifted with a relative predominance of promyelocytes and myelocytes (Figure 2).
In HAART patients, 12(44.44%) showed normal pattern of maturation in myeloid series
Giant metamyelocytes and giant band forms were seen in myeloid series
showed all stages of maturation, withdyspoiesis.
FNAC smears showed presence of myeloid series
of cells in varying stages of maturation composed of predominantly myelocytes, metamyelocytes, basophils and eosinophils.