myeloblast

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myeloblast

 [mi´ĕ-lo-blast″]
an immature cell of bone marrow, not normally found in peripheral blood; it is the most primitive precursor in the granulocytic series, which develops into the promyelocyte and eventually into a granulocyte.

my·e·lo·blast

(mī'ĕ-lō-blast),
An immature cell (10-18 mcm in diameter) in the granulocytic series, occurring normally in bone marrow, but not in the circulating blood (except in certain diseases). When stained with the usual dyes, the cytoplasm is light blue, nongranular, and variable in amount, sometimes being only a thin rim around the nucleus; the latter is deep purple-blue with finely divided, punctate, threadlike chromatin that is somewhat condensed at the periphery. A few light blue nucleoli are usually present in the nucleus, and these generally disappear as the myeloblast matures into a promyelocyte and then a myelocyte. Myeloblasts ordinarily yield a negative reaction with peroxidase.
[myelo- + G. blastos, germ]

myeloblast

(mī′ə-lə-blăst′)
n.
An immature cell of the bone marrow that is the precursor of a myelocyte.

my′e·lo·blas′tic adj.

my·e·lo·blast

(mī'ĕ-lō-blast)
An immature cell in the granulocytic series, occurring normally in bone marrow but not in the blood. When stained, the cytoplasm is light blue and variable in amount; the nucleus deep purple-blue with finely divided, punctate, threadlike chromatin. A few light blue nucleoli in the nucleus generally disappear as the myeloblast matures into a promyelocyte and then a myelocyte.
[myelo- + G. blastos, germ]

myeloblast

The bone marrow cell from which the whole series of granular white blood cells (GRANULOCYTES) derives. Up to 3% of bone marrow cells are myeloblasts.
References in periodicals archive ?
Nadali, "Study of SFRP1 and SFRP2 methylation status in patients with de novo acute myeloblastic leukemia," International Journal of Hematology-Oncology and Stem Cell Research, vol.
The new studies therefore showed that the transcription factor C/EBPa establishes a connection between the formation of pluripotent stem cells, the specification of blood cells in the bone marrow, and the generation of myeloblastic cancer cells.
Successful use of short-course high-dose methylprednisolone in a child with acute myeloblastic leukemia (FAB M2) and myeloid tumor.
The forms of myeloproliferative diseases previously described in horses include myeloblastic leukemia, chronic lymphocytic leukemia, chronic granulocytic leukemia, acute myelomonocytic leukemia, acute monocytic leukemia and eosinophilic leukemia (TAINTOR, 2012) and, more recently, acute erythroid leukemia (FORBES et al., 2011).
[USPRwire, Mon Nov 09 2015] Global Markets Direct's, '', provides an overview of the Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia)'s therapeutic pipeline.
Acute myeloblastic leukemia (AML) is a disease characterized by neoplastic transformation and differentiation disorders of progenitor cells of myeloid series.
The three patients who had VRE bacteremia episodes were a 4-month old girl who had perinatal human immunodeficiency virus (HIV) infection, a 6-year old boy who had been under intensive chemotherapy for acute myeloblastic leukemia, and a 7-year old girl under acute lymphoblastic leukemia.
A month later, however, he was diagnosed with acute myeloblastic leukemia (AML), a cancer affecting the blood and bone marrow.
Acute myeloblastic leukemia was diagnosed in a 51-year-old man in Germany in September 2012.
However, the guanidine alkaloids have demonstrated cytotoxicity against the human infiltrating ductal carcinoma ZR7531 cell line, human myeloblastic leukemia HL-60, and human glioblastoma SF-295 cells (Duarte et al., 2010; Regasini et al., 2009).
Gebhard et al., "Late effects of allogeneic bone marrow transplantation for children with acute myeloblastic leukemia in first complete remission: the impact of conditioning regimen without total-body irradiation--a report from the Societe Francaise de Greffe de Moelle," Journal of Clinical Oncology, vol.