myeloblast


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Related to myeloblast: myeloblastic leukemia

myeloblast

 [mi´ĕ-lo-blast″]
an immature cell of bone marrow, not normally found in peripheral blood; it is the most primitive precursor in the granulocytic series, which develops into the promyelocyte and eventually into a granulocyte.

my·e·lo·blast

(mī'ĕ-lō-blast),
An immature cell (10-18 mcm in diameter) in the granulocytic series, occurring normally in bone marrow, but not in the circulating blood (except in certain diseases). When stained with the usual dyes, the cytoplasm is light blue, nongranular, and variable in amount, sometimes being only a thin rim around the nucleus; the latter is deep purple-blue with finely divided, punctate, threadlike chromatin that is somewhat condensed at the periphery. A few light blue nucleoli are usually present in the nucleus, and these generally disappear as the myeloblast matures into a promyelocyte and then a myelocyte. Myeloblasts ordinarily yield a negative reaction with peroxidase.
[myelo- + G. blastos, germ]

myeloblast

/my·elo·blast/ (mi´ĕ-lo-blast″) an immature cell found in the bone marrow and not normally in the peripheral blood; it is the most primitive precursor in the granulocytic series, which matures to develop into the promyelocyte and eventually the granular leukocyte.myeloblas´tic

myeloblast

(mī′ə-lə-blăst′)
n.
An immature cell of the bone marrow that is the precursor of a myelocyte.

my′e·lo·blas′tic adj.

myeloblast

[mī′əlōblast′]
Etymology: Gk, myelos + blastos, germ
earliest recognizable precursor of the granulocytic leukocytes. The cytoplasm appears light blue, scanty, and nongranular when seen in a stained blood film. The nucleus contains distinct chromatin material in strands, together with several nucleoli. In certain leukemias a marked increase in myeloblasts is observed in the marrow and in the peripheral blood. Compare megaloblast, myelocyte, normoblast. myeloblastic, adj.
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Myeloblast

my·e·lo·blast

(mī'ĕ-lō-blast)
An immature cell in the granulocytic series, occurring normally in bone marrow but not in the blood. When stained, the cytoplasm is light blue and variable in amount; the nucleus deep purple-blue with finely divided, punctate, threadlike chromatin. A few light blue nucleoli in the nucleus generally disappear as the myeloblast matures into a promyelocyte and then a myelocyte.
[myelo- + G. blastos, germ]

myeloblast

The bone marrow cell from which the whole series of granular white blood cells (GRANULOCYTES) derives. Up to 3% of bone marrow cells are myeloblasts.

myeloblast

an immature cell of bone marrow, not normally found in peripheral blood; it is the most primitive precursor in the granulocytic series, which develops into the promyelocyte and eventually into a granulocyte.
References in periodicals archive ?
Increased eosinophilic myelocytes and myeloblasts have been interpreted as eosinophilic leukemia,[20,21] and a valuable prognostic grading system has been described by Schooley.
A CD34 IHC stain highlighted numerous immature cells consistent with myeloblasts which were arranged in aggregates and small sheets within the submucosa (Figure 3).
9]/l (check every 2 weeks until Basophils <5% CHR, then 3-monthly) No myelocytes, promyelocytes, myeloblasts in the differential count Platelet count <450x[10.
There was an increased number of immature neutrophils including all stages of neutrophil development except myeloblasts.
9] /1, left shift in the differential blood count with 8% myeloblasts and 4% erythroblasts.
The tumors are composed of myeloblasts, which are immature cells of granulocytic origin.
Multidimensional flow cytometry of marrow can differentiate leukemic from normal lymphoblasts and myeloblasts after chemotherapy and bone marrow transplantation.
MS is a localized mass of myeloblasts with or without additional immature myeloid cells.
WBCs are derived from two types of committed stem cells: myeloblasts and lymphoblasts.
The high frequency of the leukostasis syndrome during acute myeloid leukemia and the acute phase of chronic myeloid leukemia has been attributed to the low deformability of the myeloblasts.