myelinotoxic

[mi″ĕ-lin´o-tok″sik]

having a deleterious effect on myelin; causing demyelination.

References in periodicals archive ?

(2005) Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic Pr[P.sup.C].

Dual role of cellular prion protein in normal host and Alzheimer's disease

DISCUSSION: It is suggested that the rise in serum sodium exerts an osmotic endothelial injury leading to the local release of myelinotoxic factors derived from more vascular grey matter.

Piglet sign of central pontine myelinolysis

In GBS, TNF[alpha] produced by the infiltrating T cells has a direct myelinotoxic effect on myelinated fibers, causing demyelination.

Role of cytokines and toll-like receptors in the immunopathogenesis of guillain-barre syndrome

Meningeal inflammation is most commonly, but not always, associated with subpial lesions (Type III/IV), and it is theorized that myelinotoxic agents may diffuse from the meninges into the superficial gray matter, possibly contributing to demyelination [25].

Gray matter pathology in MS: neuroimaging and clinical correlations

Moreover, MMPs may contribute indirectly to the expansion of the inflammatory response and tissue damage by generating antigens through the breakdown of myelin or by conversion of inactive membrane bound TNF-[alpha] into the active myelinotoxic form [36].

The role of microglia and matrix metalloproteinases involvement in neuroinflammation and gliomas

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