Although duodenal biopsy is unnecessary when the t-TG levels are so high, a biopsy was done revealing "complete flattening of the villi with crypt hyperplasia." An MRI of the brain revealed "central pontine myelinosis
." The child was diagnosed with celiac disease and the degeneration (myelinosis
) of the pans.
Most of the benefit occurs early with this drug, and the rate of rise of serum sodium and osmolality was fairly modest in the study, which is important because a large concern with these drugs has been central pontine myelinosis
, said Steven Goldsmith, M.D., who moderated the poster session and is lead investigator of an ongoing study of conivaptan in patients with acute decompensated chronic heart failure.