(d) 24-h postketamine injection myelinated nerve fibers
(MyS), severe myeline degeneration (thin arrows) a dense mass in the axon (thick arrows).
Role of sorbitol accumulation and myo-inositol depletion in paranodal swelling of large myelinated nerve fibers
in the insulin-deficient spontaneously diabetic bio-breeding rat.
Both the diameter and myelin sheath thickness in regenerated myelinated nerve fibers
of each group were assessed in a double blind method with MOTICMED 6.0 digital medical imagine analysis system by pathological technician in our laboratory: the section of bilateral nerve segment in each group was observed under light microscope that magnified 400 times to count the quantity of myelinated nerve fibers
in four fields of vision and record the diameter and myelin sheath thickness; the average was counted and the quantity of experimental side was contrasted to the quantity of normal side to get the recovery ratio:
As expected, thresholds by fiber population decreased from large myelinated nerve fibers
to small myelinated nerve fibers
and more so for small unmyelinated nerve fibers.
In the control and OGD rats, the myelinated nerve fibers
were similar in size.
To establish the percent of myelinated nerve fibers
, the number of MBP-positive nerve fibers (regarded as myelinated) was determined in nerve profiles sectioned transversally (at least 10 per section) and compared with that of S100P-positive nerve fibers (regarded as the total number).
 Because segmental demyelination and axonal damage coexist in patients with diabetic neuropathy , nerve conduction studies, which primarily reflect the functional status of large myelinated nerve fibers
, reveal various patterns.
Myelinated nerve fibers
and retinal vascular abnormalities.
An error in process of myelination, or in the formation of the sclera, is hypothesized to be responsible for the myelin's reaching the retina (2).Oligodendrocytes responsible for myelination of the CNS, are not normally present in the human retina, but histological studies confirm their presence in some areas of myelinated nerve fibers
, and their absence in other areas (2).
Optic lobe: The optic nerve was formed from myelinated nerve fibers
that merge into the optic lobe (Fig.
The macerated samples in diluted osmium tetroxide showed a general view of myelinated nerve fibers