myc


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Myc

(mĭk)
n.
Any of several genes encoding DNA-binding proteins that can promote the development of various cancers when present at high concentrations.

myc

An oncogene on chromosome 8q24 of cellular (c-myc) or viral (v-myc) origin, which was first identified in the genome of a group of acutely transforming retroviruses capable of inducing avian neoplasia, possibly linked to RNA processing.

Physiological
c-myc is present in normal tissues; the protein product is required for progression through the cell cycle. Myc-null cell lines show profound growth defect, with lengthening of G1 and G2 phases of the cell cycle. There is a marked reduction in cyclin D1-CDK4 and D1-CDK6 complexes during entry to S phase, with lesser reductions in cyclin E2-CDK2 and cyclin A-CDK2. Myc induces expression of cyclins D1 and D2.

Pathological
Oncogenic expression of c-myc involves mutations on exon 2, which occur in more than 50% of Burkitt's lymphomas. The typical translocation in Burkitt’s lymphoma is t(8;14)(q24;q23), juxtaposing the c-myc and the immunoglobulin heavy-chain genes. Variant translocations are to 2p11 or 22q11, juxtaposing kappa or lambda light-chain genes respectively. FISH performed with dual probes can demonstrate the IgH/c-myc translocation. Tricolour with a probe against the centromere of chromosome 8 will control c-myc amplification or loss of the derivative chromosome 8; dual colour break-apart probes will show splitting of the gene.
References in periodicals archive ?
Cdk2: a key regulator of the senescence control function of Myc. Aging, 2(4):244-250.
La region N-terminal de c-Myc tiene 140 aminoacidos y contiene grupos acidos ricos en prolina y glutamina, similares a los asociados con algunos dominios de transactivacion (28, 33-35); la secuencia de la proteina c-Myc posee varios dominios N-terminales conservados, que se denominan cajas Myc, y se encuentran en proteinas homologas relacionadas, como N-Myc y L-Myc.
The experiments only succeeded because the Myc gene in the mice was modified to make it respond to the drug.
Echo Cup League (Under-15): Widnes; MYC Under-18 Midweek: Liverpool Nalgo.
Citation: Davide Seruggia et al., TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.
Cimatu's attention, who promptly went to MYC to meet with Joseph.
The newly installed top official of the country's premier yacht organization revealed that MYC has set a dialogue with all the stakeholders in Manila Bay to ensure that the wastewater they release there are safe and clean.
It was also a big day for me as it was my first time to be inside the Manila Yacht Club since Commodore Bobby Joseph accepted my challenge to have the MYC as the lead agency to help clean up Manila Bay.
Here we propose an innovative approach to inhibit myc, A non-redundant and most-wanted therapeutic target for human cancer.
The MYC, a conglomeration of over a dozen religious parties of the country, through a unanimous declaration at an emergent meeting held at Mansoora, said that the countrywide protest over the SC verdict should make it clear to the rulers that the entire nation stood united on the issue of the sanctity of the Holy Prophet.