myc


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Myc

(mĭk)
n.
Any of several genes encoding DNA-binding proteins that can promote the development of various cancers when present at high concentrations.

myc

An oncogene on chromosome 8q24 of cellular (c-myc) or viral (v-myc) origin, which was first identified in the genome of a group of acutely transforming retroviruses capable of inducing avian neoplasia, possibly linked to RNA processing.

Physiological
c-myc is present in normal tissues; the protein product is required for progression through the cell cycle. Myc-null cell lines show profound growth defect, with lengthening of G1 and G2 phases of the cell cycle. There is a marked reduction in cyclin D1-CDK4 and D1-CDK6 complexes during entry to S phase, with lesser reductions in cyclin E2-CDK2 and cyclin A-CDK2. Myc induces expression of cyclins D1 and D2.

Pathological
Oncogenic expression of c-myc involves mutations on exon 2, which occur in more than 50% of Burkitt's lymphomas. The typical translocation in Burkitt’s lymphoma is t(8;14)(q24;q23), juxtaposing the c-myc and the immunoglobulin heavy-chain genes. Variant translocations are to 2p11 or 22q11, juxtaposing kappa or lambda light-chain genes respectively. FISH performed with dual probes can demonstrate the IgH/c-myc translocation. Tricolour with a probe against the centromere of chromosome 8 will control c-myc amplification or loss of the derivative chromosome 8; dual colour break-apart probes will show splitting of the gene.
References in periodicals archive ?
Another way must be found to deactivate the Myc gene in humans.
Echo Cup League (Under-15): Widnes; MYC Under-18 Midweek: Liverpool Nalgo.
In the orthotopic Hep3B HCC model, EnCore[TM] particle formulations of DsiRNAs targeting either MYC, -catenin, or several other challenging gene targets, when administered three times per week for two weeks, resulted in up to 70 percent mRNA knockdown as well as approximately 60 percent tumor growth inhibition.
Phosphorylation of serine at position 62 by extracellular signal regulated kinase (ERK) or CDK kinases increases Myc cellular stability.
Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP.
However, in the current study researchers demonstrate that in the intact neural tissue from chickens, MYC promotes differentiation of neural cells rather than their proliferation.
Replying to a question, Sahibzada Khairi said that despite MYC's condemnation of Rawalpindi tragedy, MYC has strongly condemned any possible revengeful terrorism in response to it, and while replying to another question, it was said that there was a law against misuse of loudspeakers
Al-Shabab's recruitment drives in East African countries such as Kenya have been greatly aided by the presence of both sympathizers, such as influential religious preachers, and allied organizations, chief among them Kenya's MYC.
The protein that myc encodes, when superabundant, incites B lymphocytes to replicate out of control, Michael B.
He said: "If we can knock out the Myc even at a highly developed stage, the cancer will eventually go away.
A report due to be published this week in Nature magazine describes how the molecule, called Myc, accelerates the growth of dividing cancer cells.