mutein

mu·tein

(myū'tēn),
A protein arising as a result of a mutation or a recombinant DNA procedure.
[mutation + protein]

mutein

A protein that results from the translation of a mutation.

mu·tein

(myū'tēn)
A protein arising as a result of a mutation.
[mutation + protein]
References in periodicals archive ?
DEL106 is an IL-2 mutein Fc fusion protein designed to upregulate regulatory T cells (Tregs), which are critical to maintaining immune system balance.
DEL106 is a novel IL-2 mutein Fc fusion protein, intended to preferentially upregulate regulatory T cells, immune cells that are critical to maintaining natural self-tolerance and immune system homeostasis.
DEL106 is a novel IL-2 mutein Fc fusion protein designed to preferentially upregulate regulatory T cells (Tregs), immune cells that are critical to maintaining natural self-tolerance and immune system homeostasis.
Reteplase is a nonglycosylated deletion mutein of tPA, similar to alteplase but modified in order to achieve a longer half-life (approximately 13-16 minutes), as well as improved thrombolytic properties by binding to fibrin with a lower affinity than alteplase.
Antagonistic activities of the tumor necrosis factor receptor 1-selective mutein (R1antTNF).
From this perspective, our laboratory aims to develop a novel DDS platform to overcome problems with protein therapies by: (i) establishing a high-throughput system to validate many candidate proteins by applying a phage antibody library [i.e., an in vitro monoclonal antibody (mAb) development system] to the study of disease proteomics; (11) (ii) developing a powerful system to rapidly create functional mutant proteins (muteins) with enhanced receptor affinity and receptor specificity by using a phage display technique; (12,13) and (iii) creating a novel polymer-conjugation system to dramatically improve the in vivo stability of bioactive proteins.
Development of a system to create artificial functional muteins for advanced pharmaceutical applications
In vivo somatic cell gene transfer of an engineered Noggin mutein prevents BMP4-induced heterotopic ossification.
Accelerated healing of duodenal ulcers by oral administration of a mutein of fibroblast growth factor in rats.
Reteplase is a deletion mutein of t-PA and does not contain the kringle I, finger, and epidermal growth factor domains found on wild type t-PA and alteplase (Martin et al., 1993).
(Osaka, Japan) has patented a human parathyroid hormone mutein which comprises at least one modification selected from the group consisting of (i) deletion of 3 to 6 amino acid residues on the N-terminal side in the amino acid sequence of human parathyroid hormones, (ii) substitution of another lipophilic amino acid residue for at least one methionine residue in the amino acid sequence, and (iii) substitution of a cysteine residue for one amino acid residue within the region of amino acid residue Nos.
Herbert Grierson is mutein his edition of The Poems of John Donne (1912), but Helen Gardner gives the gist of the legend of the Seven Sleepers of Ephesus: