mutation frequency


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mutation frequency

the proportion of mutants in a population as compared with normal WILD TYPE individuals.
References in periodicals archive ?
To evaluate the interaction, we simulated the mutation frequency predicted by the model by using parameter estimates from the binomial GLM (Table 3) and either fixed values of depth or clone size across the range of observed clone sizes and depths (Fig.
The RUNX1 mutation frequency increased with age: 5-10% in patients aged <60 years and 10-20% in those aged [greater than or equal to]60 years.
To determine mutation frequency, cell samples of SC7K lys2-3 were plated after treatment on omission media (OM: 2% dextrose, 0.67% nitrogenous base yeast (Sigma-Aldrich, USA), 2% agar) (17, 18) and incubated at 30[degrees]C for 21 days.
Although not truly representative of the population across the world, we believe this work represents the largest and broadest study of EGFR mutation frequency. It will be interesting to revisit this data source in the future to determine the stability and reproducibility of the observations made in this work.
Balci et al., "Mutation frequency of familial Mediterranean fever and evidence for a high carrier rate in the Turkish population," European Journal of Human Genetics, vol.
We found 37.5% mutation frequency in rpsL gene in streptomycin-resistant isolates, similar to a study performed in Barcelona which reported 24.6% rpsL gene frequency.18 The most common (Lys43Arg and Lys88Arg) mutations in rpsL gene reported in our study have also been reported in isolates from patients in Punjab, Pakistan, and from Barcelona.1,18 Lys111Ile novel mutation detected in streptomycin-resistant isolates could have a role in streptomycin resistance.
However, while estimating the RPE65 mutation frequency in LCA patients in China may provide useful information for gene therapy of this disease, the LCA patients' cohort in our study may not have been sufficient to estimate an accurate RPE65 mutation frequency in our LCA patients given that only 1 out of 52 patients carried mutation in RPE65 .
The growth parameters including, seeds germination (%), seeds germination time, mutation frequency (%), lethality (%), stem length, leaf length, stem diameter, number of leaves, leaf surface area, flowering time, fruiting time and the number of fruits per plant, were observed during the study.
In earlier studies, the EGFR mutation frequency reportedly varied proportionally among different ethnic groups (10,11).
Differences in EGFR somatic mutation frequency among ethnic groups and geographic regions have been largely reported [18-31] (Figure 3).
Fisher's exact test was used to compare cancer incidence rate, clinical characteristics, and mutation frequency between Whites and Asians.
And it has been indicated that driver genes are related to not only mutation frequency, but also mutation context or gene length [25] and variants tend to arise more frequently in long genes [26].