Previous laboratory studies showed that the protein MFN1 could compensate for the loss of function of
mutated MFN2.
Erlotinib and osimertinib remained ineffective in cells with
mutated proteins, while the drugs showed an effect in the non-mutated cancer cells.
Conclusion: It was found that WT TP53 interactions with BRCA1 and RAD51 did not interfere with
mutated TP53 in MDA-MB-468 cell line.
"Our paper is a major advance because we identify a protein that binds to the
mutated protein and promotes its breakdown," he said.
Scientists think cows were probably the source of viruses that
mutated to cause measles and smallpox in humans.
No TPO activity was detectable with cells transfected with
mutated mRNAs.
Sir Liam said there was a 'natural cycle' in which every 10 to 40 years the flu virus
mutated into something for which there was no natural immunity and it was a question of 'when, not if'.
Sir Liam said there was a "natural cycle" in which every 10 to 40 years the flu virus
mutated into something for which there was no natural immunity.
Because women carry two copies of the X chromosome (men have one X and one Y), a defective or
mutated gene on one X strand of DNA is simply overridden by its healthier duplicate on the other.
In the course of studying the incidence of k-ras mutations in DNA in the circulation of patients with colorectal disease, we observed that our ability to detect
mutated k-ras DNA in serum varied with the method of DNA isolation.
A
mutated sheep gene co-discovered with scientists at Duke University may provide clues to the roles of certain genes in human health.
The investigators paired women-who had had invasive breast cancer diagnosed during 1970-2001 (cases) with women who had never received a diagnosis of this cancer (controls); they matched each pair for year of birth, country of residence, BRCA gene
mutated and history of ovarian cancer.
