mutasynthesis

the synthesis of new products by MUTANT ORGANISMS that have blocks in a specific biosynthetic PATHWAY so that they cannot make the end product. When provided with an unnatural SUBSTRATE (3), the pathway may be completed with the formation of a novel end product. Such an approach has been used to produce new ANTIBIOTICS.

References in periodicals archive ?

Semduramicin: design and preparation of a new anticoccidial ionophore by semisynthesis and mutasynthesis. Dev Ind Microbiol 32: 133-139.

La combinacion salinomicina/nicarbazina como anticoccidial en pollos de engorde

ambifaria and enacyloxin analogues, with a stable amide group in place of the labile ester group and other modifications to the DHCCA-derived moiety, will be produced via a mutasynthesis strategy.

NOVENA: Exploiting an unusual polyketide chain release mechanism for production of novel enacyloxin antibiotic analogues

Heide, "Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis," Antimicrobial Agents and Chemotherapy, vol.

Novel zinc(II) complexes of heterocyclic ligands as antimicrobial agents: synthesis, characterisation, and antimicrobial studies

Efforts to reprogram the biosynthesis of enterocins and wailupemycins include the mutasynthesis of analogues of enterocin with non-natural starter units in which the authors fed aryl acids to a strain of S maritimus that was incapable of producing benzoate-primed polyketides.