Mutasynthesis | definition of mutasynthesis by Medical dictionary
mutasynthesis the synthesis of new products by MUTANT ORGANISMS that have blocks in a specific biosynthetic PATHWAY so that they cannot make the end product. When provided with an unnatural SUBSTRATE (3), the pathway may be completed with the formation of a novel end product. Such an approach has been used to produce new ANTIBIOTICS.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive
Heide, "Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis
," Antimicrobial Agents and Chemotherapy, vol.
Efforts to reprogram the biosynthesis of enterocins and wailupemycins include the mutasynthesis
of analogues of enterocin with non-natural starter units in which the authors fed aryl acids to a strain of S maritimus that was incapable of producing benzoate-primed polyketides.