mutasynthesis

the synthesis of new products by MUTANT ORGANISMS that have blocks in a specific biosynthetic PATHWAY so that they cannot make the end product. When provided with an unnatural SUBSTRATE (3), the pathway may be completed with the formation of a novel end product. Such an approach has been used to produce new ANTIBIOTICS.

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

References in periodicals archive ?

Heide, "Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis," Antimicrobial Agents and Chemotherapy, vol.

Novel zinc(II) complexes of heterocyclic ligands as antimicrobial agents: synthesis, characterisation, and antimicrobial studies

Efforts to reprogram the biosynthesis of enterocins and wailupemycins include the mutasynthesis of analogues of enterocin with non-natural starter units in which the authors fed aryl acids to a strain of S maritimus that was incapable of producing benzoate-primed polyketides.