mutasynthesis

mutasynthesis

the synthesis of new products by MUTANT ORGANISMS that have blocks in a specific biosynthetic PATHWAY so that they cannot make the end product. When provided with an unnatural SUBSTRATE (3), the pathway may be completed with the formation of a novel end product. Such an approach has been used to produce new ANTIBIOTICS.
References in periodicals archive ?
Semduramicin: design and preparation of a new anticoccidial ionophore by semisynthesis and mutasynthesis. Dev Ind Microbiol 32: 133-139.
ambifaria and enacyloxin analogues, with a stable amide group in place of the labile ester group and other modifications to the DHCCA-derived moiety, will be produced via a mutasynthesis strategy.
Heide, "Antimicrobial and DNA gyrase-inhibitory activities of novel clorobiocin derivatives produced by mutasynthesis," Antimicrobial Agents and Chemotherapy, vol.
Efforts to reprogram the biosynthesis of enterocins and wailupemycins include the mutasynthesis of analogues of enterocin with non-natural starter units in which the authors fed aryl acids to a strain of S maritimus that was incapable of producing benzoate-primed polyketides.