This organic acid buildup is caused by one of three mechanisms: genetic defect or absence of the enzyme methylmalonic acid coenzyme A
mutase (mut), defect in the synthesis and transport of mut's cofactor 5'-deoxyadenosylcobalamin, and defect in the mitochondrial transport of cobalamin.
Moreover, the recent discovery of the whole synthesis pathway of Pyl, with PylB being a lysine
mutase [13] shows that Pyl is entirely a derivative of a proteogenic amino acid (two lysines) and this could make sense in the light of the coevolution theory, such are the cases of Asp/Asn and Glu/Gln in Archaea[63].
Another enzyme, hydroxylaminobenzene
mutase, catalyzes the conversion of hydroxylaminobenzene to 2-aminophenol through Bamberger rearrangement (Figure 2).
2011, details unpublished), phosphoglycerate kinase (PfPGK) [24], and phosphoglycerate
mutase (PfPGM) [25] have been solved.
In mammalian cells, CNCbl and OHCbl are inactive forms and AdoCbl acts as a coenzyme of methylmalonyl Co-A
mutase in mitochondria.
Molecular modeling, dynamics, and an insight into the structural inhibition of cofactor independent phosphoglycerate
mutase isoform-1 from Wuchereria bancrofti using cheminformatics and mutational studies.
These genes include both the myosin heavy and light chain, and the phosphoglycerate
mutase 2 (pgam2) gene.
MMA is a compound that can build up in the bloodstream if there isn't enough vitamin B12 in the body for an enzyme, methylmalonyl-CoA
mutase, to function properly.
This vitamin exerts its physiological action through two enzymatic pathways: the first acts as a co-factor for the methionine synthase enzyme that converts homocysteine into methionine and the second acts upon L-methylmalonyl Coenzyme A (CoA)
mutase enzyme to convert methylmalonyl-CoA into succinyl-CoA4.
Celano, "Evaluation of a Nested-PCR assay based on the phosphoglucosamine
mutase gene (glmM) for the detection of Helicobacter pylori from raw milk" Food Control, vol.
The Helicobacter pylori ureC gene codes for a phosphoglucosamine
mutase. J Bacteriol 1997; 179:3488-3493.
MMA can build up in the bloodstreamif there is not enough vitamin [B.sub.12] in the body for an enzyme (methylmalonyl-CoA
mutase) to function properly.
