Lastly, for 12 out of the 106 substances, a harmonized CLP classification for mutagenicity
index (MTI) in Allium cepa cells exposed to different concentrations of (a) Aluminum, (b) Manganese and (c) Lead.
EGMAX, FEED-X, KOLIN PLUS, and STODI at the tested concentrations did not induce any significant mutagenicity
in all the tester strains of S.
and genotoxicity of suspended particulate matter in the Seine river estuary.
extracts inhibit the mutagenicity
in microsuspension assay and the proliferation of HeLa cells," Journal of Food Science, vol.
In our present work, we confirmed the chemical transformation (natural alkalization) of ZnO NPs into [Zn.sub.5][(C[O.sub.3]).sub.2][(OH).sub.6], Zn[(OH).sub.2], and [Zn.sup.2+] (Figure 1), as well as changes in the chemical properties that could result in variations in ZnO NP cytotoxicity and mutagenicity
, especially the mutagenic potential of ZnO NPs given at the [LC.sub.100].
Furthermore, an impurity with a structural alert that is shared (e.g., the same structural alert in the same position and chemical environment) with the drug substance or related compounds can be considered as nonmutagenic if the testing of such material in the bacterial mutagenicity
assay was negative .
(b) MI: mutagenicity
index: ratio of the number of revertant colonies induced by the samples/spontaneous number by the negative control.
In this study, the micronucleus test, a common biomarker of mutagenicity
, was effective in assessing the damage caused by soil contaminants on the health of the animals studied.
Crumb rubber leachates made at 40[degrees]C from fields A, B, C and D showed no significant increase in mutagenicity
They did so by measuring 1,1-diphenyl-2-picrylhydrazyl radical scavenging capacity and mutagen inhibitory activity through the Salmonella mutagenicity
In the absence of metabolic activation S9, no mutagenicity
was detected in tested strains TA98 and TA100 for both mushroom A and mushroom B.