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An alkaloid extracted from the poison mushroom Amanita muscaria; selectively stimulates receptors for γ-aminobutyric acid (GABA) and is used as a molecular probe to study GABA receptors; a potent CNS depressant, muscimol inhibits motor function; exposure can lead to psychosis; 3-aminometnyl-3-hydroxyisoxazole.
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References in periodicals archive ?
Toxicity of muscimol and ibotenic acid containing mushrooms reported to a regional poison control center from 2002-2016.
[44.] Monda M, Amaro S, Sullo A, De Luca B (1995) Injection of muscimol in the posterior hypothalamus reduces the PGE1-hyperthermia in the rat.
The alkaloid includes sanguinarine, muscimol, glycosin, ergotamine, ergobasine, mescaline, pilosine and nordihydrocapsaicin were identified from the potential extract and its fraction (Selvaraj et al.
and another active ingredient, muscimol, but chose UV detection for
Methods: According to dose test, rats were randomly divided into control (Con), Ex, muscimol (MUS, 0.1 mg/kg) and bicuculline (BIC, 0.5 mg/kg) groups, then all rats underwent once swimming Ex except ones in Con group only underwent training.
Control rats received infusions of muscimol, a chemical that inactivates neurons in these brain regions, before receiving ketamine (Proc.
Sharif, "Modification by muscimol of naloxone-precipitated withdrawal symptoms in morphine-dependent mice," General Pharmacology, vol.
Cardiovascular Responses to Muscimol Microinjected into the VTA
The applications of non-classical bioisosterism have also been reported in a number of areas of pharmacology including adrenergic and anti adrenergic drugs [28, 30-31] , several NSAID classes like aryl acetic acid derivatives [32], cetroplac, tolmetin, indomethacin, etodolac [5], antibacterial drugs [33] , antidepressant of morpholine class [34] , neuropeptide substance P antagonists (NK1 antagonists) [35], cholinergic (muscarinic type) agonists [36], GABA modulators like muscimol, thiomuscimol, isomuscimol as agonists [37-38], peptidomimetics [39], diuretics like ethacrinic acid [5] and 5-hyderoxy tryptamine (5-HT1A;1D) agonists like naratryptan and sumatryptan for acute attack of migraine [40].
In order to block MnPO pharmacologically, muscimol (4 mM) was nanoinjected (100 nL) in experimental group (EXP).