muscarinic receptors

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Related to muscarinic receptors: cholinergic receptors

mus·ca·rin·ic re·cep·tors

membrane-bound proteins with an extracellular domain that contains a recognition site for acetylcholine (ACh); combination of Ach with the receptor initiates a physiologic change (slowing of heart rate, increased glandular secretory activity, and stimulation of smooth muscle contractions); changes are observed after treatment with the mushroom alkaloid muscarine. Muscarinic receptors are to be distinguished from nicotinic receptors.


pertaining to the transmission of nerve impulses mediated by muscarinic receptors; these may be adrenergic or cholinergic.

muscarinic activity
includes slowing and reduced stroke volume of the heart, bronchiolar constriction, arteriolar dilatation, increased tone, motility and secretion in the alimentary tract, and increases in salivation and lacrimation.
muscarinic blocking agents
block muscarinic receptors, e.g. atropine and the synthetic agents homatropine, methantheline, propantheline and methylatropine.
muscarinic receptors
cholinergic receptors of autonomic effector cells (and also on some autonomic ganglion cells and some central neurons) that are stimulated by muscarine and parasympathomimetic drugs and antagonized by atropine.
References in periodicals archive ?
Expression of muscarinic receptor subtypes in rat gastric smooth muscle: Effect of M3 selective antagonist on gastric motility and emptying.
Muscarinic receptors were determined by binding assays using a single concentration (Kd) of the specific tritiated ligand antagonist [sup.
Antispasmodic and bronchodilator activities of Artemisia vulgaris are mediated through dual blockade of muscarinic receptors and calcium influx.
Regulation of rat mesencephalic GABAergic neurones through muscarinic receptors.
There are five subtypes of muscarinic receptors expressed in the bladder.
These results indicate that the activation of SERCA and muscarinic receptors may play an important role in the effect of DECC on the cardiac contractility, heart rate and coronary flow.
The concept of muscarinic receptors originated from a report by Dale in 1914, (1) although he did not use the term receptor.
When bound to the muscarinic receptors, Ach is suppressed, allowing for sympathetic nervous system symptoms ("fight or flight") to activate.