Bactroban

(redirected from mupirocin cream)

mupirocin (pseudomonic acid, pseudomonic acid A)

Bactroban, Bactroban Nasal 2%, Taro-Mupirocin (CA)

Pharmacologic class: Dermatologic agent

Therapeutic class: Anti-infective, topical

Pregnancy risk category B

Action

Inhibits bacterial protein and RNA synthesis by reversibly and specifically binding to bacterial isoleucyl-transfer RNA synthetase. Bactericidal.

Availability

Intranasal ointment: 2.15%

Topical cream: 2%

Topical ointment: 2%

Indications and dosages

Impetigo

Adults and children ages 2 months to 16 years: Apply a small amount of ointment topically t.i.d. for 3 to 5 days. Reevaluate if no response.

Infected traumatic skin lesions

Adults and children ages 3 months to 16 years: Apply a small amount of cream topically t.i.d. for 10 days.

Nasal colonization of methicillin-resistant Streptococcus aureus

Adults and children ages 12 and older: Apply intranasal ointment (half of single-use tube to each nostril) topically to anterior nares b.i.d. for 5 days.

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• moderate or severe renal impairment (with large doses)

• breastfeeding patients

• children younger than age 12 (intranasal ointment), younger than age 3 months (cream), or younger than age 2 months (ointment).

Administration

• After intranasal application, press nares together repeatedly to distribute drug.

• Avoid contact with eyes.

• Discontinue use if sensitization or severe local irritation occurs.

• If desired, cover affected area with gauze dressing after applying cream or ointment.

• Don't use intranasal form with any other nasal spray.

• Don't use Bactroban ointment on mucosal surfaces. Use Bactroban Nasal (mupirocin calcium ointment) intranasally.

• Know that although mupirocin isn't absorbed systemically, polyethylene glycol (its water-miscible ointment base) may be absorbed from open wounds and damaged skin and may be excreted by the kidneys.

Adverse reactions

CNS: headache (with intranasal use)

EENT: rhinitis, nasal stinging or burning, pharyngitis (all with intranasal use)

GI: mouth and lip sores

Skin: pruritus (with intranasal use); dry skin, rash, redness, stinging or pain, secondary wound infection

Other: taste disorders (with intranasal use)

Interactions

None significant

Patient monitoring

• Monitor for drug efficacy.

Patient teaching

• Instruct patient to wash affected area with soap and water and dry it thoroughly, then apply small amount of drug to area and rub in gently. If desired, tell him to apply gauze dressing.

• Advise patient to complete entire course of therapy, even if symptoms disappear. Tell him to try not to miss doses.

• If patient misses a dose, tell him to apply dose as soon as he remembers. However, if it's almost time for next dose, advise him to skip missed dose and resume regular dosing schedule.

• Advise patient to contact prescriber if skin infection doesn't improve within 3 to 5 days or if it worsens.

• Caution patient not to apply drug to eye or mucous membranes (except nasal form for intranasal use).

• As appropriate, review all other significant adverse reactions.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved

Bactroban

(băk′trə-băn′)
A trademark for the drug mupirocin calcium.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

Bactroban

A topical antibiotic for treating traumatic skin lesions with secondary infection by susceptible strains of Staphylococcus aureus, methicillin-resistant S aureus (MRSA) and Streptococcus pyogenes,
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

Bactroban®

Mupirocin cream A topical antibiotic for treating traumatic skin lesions with 2º infection by susceptible strains of Staphylococcus aureus, methicillin-resistant S aureus–MRSA, Streptococcus pyogenes
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Group A comprised 90 patients who underwent septoplasty and who were packed with mupirocin cream (Bactroban 2% cream, Glaxo Smith Kline, Istanbul, Turkey)-soaked silicone nasal septal splints with integral airway (DOYLE splint; Boston Medical Products, MA, USA) in both nasal cavities.
Group B comprised 76 patients who underwent septoplasty and who were packed with mupirocin cream (Bactroban 2% cream; GlaxoSmithKline, Istanbul, Turkey)-soaked PVA sponge Merocel (Medtronic, Connecticut, USA) with integral airway in both nasal cavities.
Patient was started on oral doxycycline, topical mupirocin cream and clotrimazole 1% cream.
Application of mupirocin cream at the exit-site reduces exit-site infections and peritonitis in peritoneal dialysis patients.
In our case, antiseptic wet dressing and mupirocin cream were used to treat Orf; topical and systemic steroids and cetirizine were used to treat erythema multiforme.
Application of mupirocin cream at the catheter exit site reduces exit-site infections and peritonitis in peritoneal dialysis patients.
Mupirocin cream is as effective as oral cephalexin in the treatment of secondarily infected minor wounds and, because of better tolerability, is the treatment of choice for the prevention and treatment of Staphylococcus aureus and Staphylococcus pyogenes infections.
Another study with 2 parallel, identical RCTs of a total of 706 patients found mupirocin cream (Bactroban) to be equivalent to oral cephalexin in the treatment of secondarily infected minor wounds, such as small lacerations, abrasions, or sutured wounds.
In the past year Glenmark has received approval for seven products including rizatriptan benzoate tablets, rizatriptan benzoate OD tablets, mupirocin cream, zolmitriptan tablets, zolmitriptan OD tablets, riluzole tablets and acamprosate calcium DR tablets.
Application of mupirocin cream at the catheter exit site reduces exit-site infection and peritonitis in peritoneal dialysis patients.
We compared mupirocin cream with oral cephalexin in the treatment of wounds such as small lacerations, abrasions, or sutured wounds.