multistage carcinogenesis

multistage carcinogenesis

A general term referring to the development of cancer through multiple steps of oncogene activation and tumor suppressor inactivation. See One-hit, two-hit model, p53, Tumor.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The mouse skin model of multistage carcinogenesis has been used for over 60 years and is one of the most well-established in vivo models for studying the stepwise and chronological development of epithelial tumors [11, 12].
DiGiovanni, "Multistage carcinogenesis in mouse skin," Pharmacology and Therapeutics, vol.
The classic and mechanistically groundbreaking studies on polycyclic aromatic hydrocarbons (PAHs) are used to convey critical concepts on multistage carcinogenesis, including initiation, promotion, and progression.
2002, Multistage carcinogenesis and the incidence of colorectal cancer.
Cancer results from a multistage carcinogenesis process that involves three distinguishable but closely connected stages initiation, promotion and progression [1].
Here we summarize recent Cr(VI)-induced human tumour, in vivo, cell culture and in vitro studies and put the data into context with three major paradigms of carcinogenesis: multistage carcinogenesis, genomic instability, and epigenetic modifications.
Three well-accepted general paradigms of carcinogenesis include multistage carcinogenesis, genomic instability, and epigenetic modification.
The mouse skin model of multistage carcinogenesis has demonstrated that cancer development results from the coordination of genetic mutation and alterations of epigenetic factors, including the machineries regulating cell proliferation and apoptosis (Hecker 1987; Zoumpourlis et al.
Multistage carcinogenesis consists of initiation, promotion, and progression.
Dose-response relationship in multistage carcinogenesis: promoters.
The modified multistage carcinogenesis model for SHE cell neoplastic progression is shown in Figure 1.
Multistage carcinogenesis involves multiple genes and multiple mechanisms.
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