multiple-system atrophyAn uncommon (5/105) neurodegenerative disorder (”tauopathy”) with incomplete penetrance, characterised by:
(2) Ataxia, and
(3) appearance in those aged 55 to 65.
Parkinsonism, cerebellar dysfunction (e.g, ataxia), incoordination, autonomic dysfunction (e.g, orthostatic hypotension), urinary incontinence, impotence, constipation, dry mouth, temperature dysregulation.
Symptomatic and supportive.
Slow, inexorable deterioration; death commonly within 10 years.
multiple-system atrophyNeurology A heterogenous group of neurologic syndromes– corticobasal ganglionic degeneration, olivopontine cerebellar atrophy, progressive supranuclear palsy, Shy-Drager syndrome, striatonigral degeneration–which share features caused by lesions of interrelated groups of neurons
mul·ti·ple-sys·tem at·ro·phy(mŭl'ti-pĕl sis'tĕm at'rŏ-fē)
Nonhereditary, neurodegenerative disease of unknown cause, characterized clinically by the development of parkinsonism, ataxia, autonomic failure, or pyramidal tract signs, in various combinations. Pathologically there are nerve cell loss, gliosis, and the accumulation of abnormal tubular structures in the cytoplasm and nucleus of oligodendrocytes and neurons in the basal ganglion, cerebellum,and intermediolateral columns of the spinal cord; can present as predominantly parkinsonism, as predominantly ataxia, or as a combination of parkinsonism, ataxia, and autonomic failure; it is a relatively rapidly progressive and fatal disorder.
mul·ti·ple-sys·tem at·ro·phy(MSA) (mŭl'ti-pĕl sis'tĕm at'rŏ-fē)
Nonhereditary, neurodegenerative disease of unknown cause, characterized clinically by the development of parkinsonism, ataxia, autonomic failure, or pyramidal track signs, in various combinations.