multiple system atrophy

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multiple system atrophy (MSA),

a nonhereditary, neurodegenerative disease of unknown cause, characterized clinically by the development of parkinsonism, ataxia, autonomic failure, or pyramidal track signs, in various combinations. Pathologically there are nerve cell loss, gliosis, and the accumulation of abnormal tubular structures in the cytoplasm and nucleus of oligodendrocytes and neurons in the basal ganglion, cerebellum, and intermediolateral columns of the spinal cord; can present as predominantly parkinsonism, as predominantly ataxia, or as a combination of parkinsonism, ataxia, and autonomic failure; it is a relatively rapidly progressive and fatal disorder. Labeled MSA-P when parkinsonism predominates but MSA-C, when cerebellar ataxia predominates.
Farlex Partner Medical Dictionary © Farlex 2012

multiple system atrophy

A progressive neurodegenerative disorder characterized by low blood pressure, incontinence, impotence in men, sleep disturbance, and parkinsonism or cerebellar ataxia.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive ?
(NYSE: BHVN) ('Biohaven' or the 'Company'), a clinical stage biopharmaceutical company with a portfolio of late-stage product candidates for neurological and neuropsychiatric diseases, announced today that it enrolled the first patient in a Phase 3 clinical trial to evaluate the efficacy and safety of verdiperstat in subjects with Multiple System Atrophy ('MSA').
Multiple System Atrophy is a currently non-curable neurological disorder characterized by neurodegeneration in several parts of the brain including the basal ganglia and the cerebellum.
Troy, a veteran firefighter, opted to die quickly, by lethal injection, rather than slowly from multiple system atrophy.
The walkathon is an important awareness initiative as we continue to fight multiple system atrophy," said Ritje Schouppe-Moons, Chief Executive of the AMS-MSA Belgium, organizer of the yearly "JiePie Award for MSA Research" and Spokesperson for World MSA Day, observed on October 3rd.
Biopharmaceutical company Biohaven Pharmaceutical Holding Company Ltd (NYSE:BHVN) said on Wednesday that it plans to proceed with its clinical investigation of BHV-3241 for the potential treatment of multiple system atrophy (MSA) following the the US Food and Drug Administration (FDA) may proceed letter.
Family flowers only please; donations if desired for the benefit of the Multiple System Atrophy (MSA) Trust.
The highest mortality was seen for patients with atypical parkinsonism (multiple system atrophy or progressive supranuclear palsy).
Multiple System Atrophy (MSA) causes nerve cells in the brain to deteriorate over time.
In an email addressed to colleagues, O'Callaghan, 57, said he has multiple system atrophy, a neurodegenerative disease that destroys the body's central nervous system.
His courage was never more evident than during his prolonged fight against Multiple System Atrophy. He knew the spiteful condition couldn't be beaten, but the fortitude he showed and the grace with which he battled the illness were typical of him.
Multiple system atrophy (MSA) is an adult onset, progressive, idiopathic neurodegenerative disease that clinically manifest as MSA-C with cerebellar signs predominant, MSA-P with Parkinsonian features predominant and MSA-A with autonomic signs and symptoms.
Schroeder, "Quadratus lumborum block as sole, homeostatic-preserving anesthetic for a patient with multiple system atrophy undergoing open inguinal hernia repair: a case report," Case Reports in Anesthesiology, vol.

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