multiple system atrophy


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multiple system atrophy (MSA),

a nonhereditary, neurodegenerative disease of unknown cause, characterized clinically by the development of parkinsonism, ataxia, autonomic failure, or pyramidal track signs, in various combinations. Pathologically there are nerve cell loss, gliosis, and the accumulation of abnormal tubular structures in the cytoplasm and nucleus of oligodendrocytes and neurons in the basal ganglion, cerebellum, and intermediolateral columns of the spinal cord; can present as predominantly parkinsonism, as predominantly ataxia, or as a combination of parkinsonism, ataxia, and autonomic failure; it is a relatively rapidly progressive and fatal disorder. Labeled MSA-P when parkinsonism predominates but MSA-C, when cerebellar ataxia predominates.

multiple system atrophy

n.
A progressive neurodegenerative disorder characterized by low blood pressure, incontinence, impotence in men, sleep disturbance, and parkinsonism or cerebellar ataxia.
References in periodicals archive ?
SYMPATH aims to advance the clinical development of therapeutic vaccines targeting alpha- Synuclein-driven neurodegenerative diseases including Parkinson's disease (PD) and multiple system atrophy (MSA) where no causal therapy currently exists.
Supporting patients and caregivers affected by multiple system atrophy
65) The term multiple system atrophy (MSA) was proposed to cover a whole array of "disease entities" which, according to the author, are in fact merely the expression of neuronal atrophy in a variety of overlapping combinations, including progressive autonomic failure.
a) n Baseline 1 h L-DOPS Healthy volunteer 2 N/A 3696 (2011) Pure autonomic failure 7 N/A 1762 (550) Multiple system atrophy 1 N/A 1169 Parkinson disease and 3 N/A 3205 (2171) orthostatic hypotension (b) NE Healthy volunteer 2 1.
Consensus statement on the diagnosis of multiple system atrophy.
Key words: Alzheimer disease, amyotrophic lateral sclerosis, electromagnetic fields, metals, multiple system atrophy, neurodegeneration, Parkinson disease, pesticides, progressive supranuclear palsy, solvents.
Their laboratory studies, using mice, suggest that genes involved in iron metabolism, or lack thereof, may be the cause of Parkinson's and other diseases in which excessive brain iron has been noted, such as Friedrich's Ataxia, Hallervorden-Spatz disease, and multiple system atrophy (formerly known as olivopontocerebellar atrophy).
DaTscan may be used to help differentiate essential tremor from tremor due to PS (idiopathic Parkinson's disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP)).
nOH is a rare disease that occurs in people with an existing disease of the brain, spinal cord, or peripheral nerves, including Parkinson's disease, multiple system atrophy (MSA), and pure autonomic failure (PAF).
Family flowers only please but donations would be appreciated for The Multiple System Atrophy Trust c/o T.
An international consortium of top European research teams has received significant EU funding for the development of therapeutic vaccines against Parkinson's Disease (PD) and Multiple System Atrophy (MSA).

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