multiple system atrophy


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multiple system atrophy (MSA),

a nonhereditary, neurodegenerative disease of unknown cause, characterized clinically by the development of parkinsonism, ataxia, autonomic failure, or pyramidal track signs, in various combinations. Pathologically there are nerve cell loss, gliosis, and the accumulation of abnormal tubular structures in the cytoplasm and nucleus of oligodendrocytes and neurons in the basal ganglion, cerebellum, and intermediolateral columns of the spinal cord; can present as predominantly parkinsonism, as predominantly ataxia, or as a combination of parkinsonism, ataxia, and autonomic failure; it is a relatively rapidly progressive and fatal disorder. Labeled MSA-P when parkinsonism predominates but MSA-C, when cerebellar ataxia predominates.

multiple system atrophy

n.
A progressive neurodegenerative disorder characterized by low blood pressure, incontinence, impotence in men, sleep disturbance, and parkinsonism or cerebellar ataxia.
References in periodicals archive ?
Keywords: Hot cross bun sign, Multiple system atrophy, MRI, Neurodegenerative disease.
A Multiple system atrophy (MSA) is a progressive neurological disease whose cause is unknown.
Both Parkinson's disease (PD) and multiple system atrophy (MSA) have associated sleep disorders related to the underlying neurodegenerative pathology, such as abnormal sleep architecture, rapid eye movement sleep behavior disorder (RBD), excessive daytime sleepiness, restless legs syndrome, periodic limb movement disorder, and circadian dysfunction.
However, CSF samples at baseline could not distinguish multiple system atrophy from Parkinson's disease.
Alex's mum Sharon Cannon had Multiple System Atrophy (MSA) which is such a horrible disease.
Another limitation of this this study is that we did not include the Progressive Supranuclear Palsy (PSP) Rating Scale [31] and the Unified Multiple System Atrophy Rating Scale (UMSARS) [32], which are the standard clinical research scales for those diseases.
Epidemiological evidence on multiple system atrophy.
In collaboration with CNRS and the University of Antwerp, KU Leuven neurobiologists have discovered that the shape of these aggregates cylinders' or ribbons' determines whether a patient develops Parkinson's disease or Multiple System Atrophy, respectively.
Although psychiatric symptoms are not part of the diagnostic criteria for multiple system atrophy (MSA), they may serve as a clue to consider when they occur with other MSA symptoms.
The protein plays a key role in the onset and progression of Parkinson's as well as multiple system atrophy (MSA), an orphan disease.
Oswald''s Hospice and Multiple System Atrophy for which a box will be provided at the crematorium.

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