multiple neurofibroma


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multiple neurofibroma

The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive ?
(a) Pelvis computed tomography scan showed multiple bone defect of sacrum and iliac bones and enlargement of sacral foramina (arrowhead) corresponding to multiple neurofibromas. (b) Pelvis computed tomography scan showed a sacroiliac joint space narrowing associated with sclerosis and microgeodes (arrow).
Also known as von Recklinghausen disease type 1, the most important component of this disorder is the multiple neurofibromas. These patients are also predisposed to develop a variety of non-neoplastic manifestations and tumors including vascular lesions, lipoma, gastrointestinal stromal tumor, pheochromocytoma, Wilms' tumor and melanoma.
Even though this sign remains controversial, it has been described during a wide range of malignancies.4 Also the acute eruption of seborrheic keratoses in association with erythroderma secondary to an inflammatory dermatose like psoriasis has been reported.10 In this case the diagnosis of SNF was established by the presence of multiple neurofibromas localized on the trunk dermatomally without an affected family member or systemic involvement.
Von Recklinghausen's disease or neurofibromatosis 1 is an autosomal dominant disorder with multiple neurofibromas and schwannomas, along with cafe au lait spots and axillary freckling.
DISCUSSION: Endolaryngeal neurofibromas are seen occasionally, of which solitary neurogenic tumors are common than multiple neurofibromas. If a neurofibroma is seen, other manifestations like axillary freckling, cafe-au-lait spots and family history should be enquired carefully.
Multiple neurofibromas are more often discovered in the jejunum, stomach, ileum, duodenum and colon according to the frequency of the their appearance.
(2) In 1975, Pen'kovskii reported a neurofibroma of the tonsil in a 61-year-old Russian woman with multiple neurofibromas. (5)
* Multiple neurofibromas (tumors on, under, or hanging off the skin).
(5) Multiple neurofibromas are associated with von Recklinghausen's disease (neurofibromatosis type 2).
In the present study 2 patients of paraplegia had multiple neurofibromas with cafe-au-lait spots and axillary freckles, one among them had spinal neurofibromas, and one had scoliosis.
Physical examination revealed multiple neurofibromas (including plexiform variety) of the chest and trunk, multiple cafe-au-lait spots of the axillary and gluteal areas and trunk, scoliosis and a Lisch nodule of the right eye.

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