multiple lentigines syndrome

LEOPARD syn·drome

[MIM*151100]
syndrome consisting of lentigines (multiple), electrocardiographic abnormalities, ocular hypertelorism, pulmonary stenosis, abnormalities of genitalia, retardation of growth, and deafness (sensorineural). An autosomal dominant hereditary disorder.

multiple lentigines syndrome

An autosomal dominant [MIM 151100] condition with thousands of 1–5-mm darkly pigmented macules on the skin

LEOPARDsyndrome

An autosomal dominant condition (OMIM:151100) with variable expression, characterised by thousands of 1–5-mm darkly pigmented macules on the skin, often of the trunk and neck, but not on mucosae. The acronym LEOPARD comes from its clinical symptoms:
▪ Lentigines;
▪ EKG disturbances;
▪ Ocular hypertelorism;
▪ Pulmonary stenosis;
▪ Abnormalities of genitalia (gonadal or ovarian hypogonadism, cryptorchidism, delayed puberty);
▪ Retarded growth;
▪ Deafness (sensorineural, i.e., nerve deafness).

multiple lentigines syndrome

LEOPARD syndrome Dermatology An AD condition with variable expression, characterized by thousands of 1-5 mm darkly pigmented macules on the skin often of the trunk and neck, but not on mucosae Clinical Sx = mnemonic acronym LEOPARD–Lentigines, EKG disturbances, Ocular hypertelorism, Pulmonary stenosis, Abnormalities of genitalia–gonadal or ovarian hypogonadism, cryptorchidism, delayed puberty, retarded growth, nerve deafness, prominent ears. See Lentigo.
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