multiple hamartoma


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multiple hamartoma

A congenital malformation that presents a slowly growing mass of abnormal tissue in multiple sites. The tissues are appropriate to the organ in which the hamartomas are located but are not normally organized. They may appear in blood vessels as hemangiomata, and in the lung and kidney. They are not malignant but cause symptoms because of the space they occupy.
See also: hamartoma
References in periodicals archive ?
Cowden's disease is a hereditary disorder characterized by oropharyngeal fibrosis and multiple hamartomas with potential malignant changes.
(3) The differential diagnosis of these papules includes: gingival fibrous nodule, papilloma, focal epithelial hyperplasia, fibroma, gingival cyst, multiple hamartomas, and exostosis.
An autosomal dominant expression of a mutation in the PTEN gene (a protein tyrosine phosphatase) also causes this disease's characteristic multiple hamartomas and predisposition to a variety of tumors.

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