multiple endocrine neoplasia


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Related to multiple endocrine neoplasia: Multiple endocrine neoplasia type 1, Multiple endocrine neoplasia type 2

neoplasia

 [ne″o-pla´zhah]
the formation of a neoplasm.
cervical intraepithelial neoplasia (CIN) dysplasia of the cervical epithelium, often premalignant, characterized by various degrees of hyperplasia, abnormal keratinization, and the presence of condylomata.
multiple endocrine neoplasia (MEN) a group of rare hereditary disorders of autonomous hyperfunction of more than one endocrine gland. In Type I (MEN I), called also Wermer's syndrome, there are tumors of the pituitary, parathyroid gland, and pancreatic islet cells in association with a high incidence of peptic ulcer. Type II (MEN II), called also Sipple's syndrome, is characterized by medullary carcinoma of the thyroid, pheochromocytoma, often bilateral and multiple, and parathyroid hyperplasia. Type III (MEN III), called also mucosal neuroma syndrome, resembles Type II except that parathyroid hyperplasia is rare, the mean survival time is shorter, and there may be neuromas and neurofibromas. All forms are transmitted as autosomal dominant traits.

multiple endocrine neoplasia (MEN),

a group of disorders characterized by functioning tumors in more than one endocrine gland.

multiple endocrine neoplasia (MEN)

a hereditary hormonal disorder that occurs in an autosomal-dominant pattern. The endocrine neoplasms may be expressed as hyperplasia, adenoma, or carcinoma and may develop synchronously or metachronously. Some kinds are multiple mucosal neuroma syndrome, Sipple's syndrome, and Werner's syndrome. See also multiple endocrine neoplasia, type I, and multiple endocrine neoplasia, type II.

multiple endocrine neoplasia, type I

a type of multiple endocrine neoplasia that includes tumors of the pituitary, parathyroid glands, and pancreatic islet cells, often with peptic ulcers and sometimes the Zollinger-Ellison syndrome. See also multiple endocrine neoplasia.

multiple endocrine neoplasia, type II

a type of multiple endocrine neoplasia characterized by medullary carcinoma of the thyroid, pheochromocytoma, and hyperplasia of the parathyroid glands. See also multiple endocrine neoplasia.

multiple endocrine neoplasia

See MEN.

mul·ti·ple en·do·crine ne·o·pla·si·a

(MEN) (mŭlti-pĕl endō-krin nēō-plāzē-ă)
A group of disorders characterized by functioning tumors in more than one endocrine gland.

Multiple endocrine neoplasia

Abnormal tissue growth on one or more of the endocrine (hormone-secreting) glands.

mul·ti·ple en·do·crine ne·o·pla·si·a

(MEN) (mŭlti-pĕl endō-krin nēō-plāzē-ă)
Group of disorders characterized by functioning tumors in more than one endocrine gland.
References in periodicals archive ?
Long -term Biochemical Results after Operative Treatment of Primary Hyperparathyroidism Associated with Multiple Endocrine Neoplasia Types I and Ila: Is a More or Less Extended Operation Essential.
Acromegaly caused by growth hormone-relating hormone in a patient with multiple endocrine neoplasia type I.
Familial cutaneous lichen amyloidosis in association with multiple endocrine neoplasia type 2A: a new variant.
Key Words: bowel obstruction, intestinal neuroma, multiple endocrine neoplasia type 2.
7] Human genes: MEN1, multiple endocrine neoplasia 1; RET, ret protooncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease).
4) Multiple endocrine neoplasia type 1 (MEN-1) is also seen in 25% of patients with thymic carcinoid.
Patients may have a history of neck irradiation, a family history of multiple endocrine neoplasia, familial hyperparathyroidism, or familial hyperparathyroidism with a jaw tumor; the latter is suggestive of parathyroid cancer.
2), (8) Multiple endocrine neoplasia Type I is present in 7.
DIAGNOSIS: Multiple endocrine neoplasia (MEN), type 1.
is contraindicated in patients with a personal or family history of MTC and in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
Pancreatic endocrine neoplasms are usually sporadic but may be part of hereditary syndromes mostly including multiple endocrine neoplasia type 1 (MEN-1) and, more rarely, von Hippel-Lindau (VHL) syndrome, neurofibromatosis type 1 (NF1), and tuberous sclerosis complex (TSC).
In 2 of these 14 cases, multiple endocrine neoplasia was subsequently diagnosed.

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