multilineage

multilineage

(mŭl″tē-lĭn′ē-ĭj) [″ + ″]
Derivation from multiple ancestors. In hematology, it is applied to cellular proliferation affecting several blood cell types.
References in periodicals archive ?
Effect of isolation methodology on stem cell properties and multilineage differentiation potential of human dental pulp stem cells.
Pooled myelopreservation and patient-reported outcomes (PRO) data from all three trilaciclib SCLC trials presented at MASCC 2019 showed significant multilineage benefits across neutrophils, red blood cells and platelets, and significantly improved symptoms and function across multiple parameters over time compared to placebo.
2016 WHO Classification of y/Sex Cellularity, Myeloid Neoplasms and Acute % Leukemia) 1 AML with myelodysplasia- 82/F 80 related changes 2 MDS/MPN with history of 80/M 95 MDS-EB 3 MDS with isolated del(5q) 79/F 20-30 4 MDS-EB 86/M <10 5 MDS with multilineage 83/M 80-90 dysplasia 6 MDS, unclassifiable 24/M 20 7 MDS with multilineage 71/M 30-40 dysplasia 8 MDS with isolated del(5q) 67/M 50-60 9 MDS, unclassifiable 74/M 60 10 MDS, unclassifiable 72/F 40 11 MDS with isolated del(5q) 83/M 30 Patient Cytogenetics and/or Histologic Findings No.
Clonal SA is related to various MDS subcategories including refractory anemia with ring sideroblasts (RARS), refractory cytopenias with multilineage dysplasia with ring sideroblasts (RCMD-RS) and refractory anemia with ring sideroblasts and thrombocytosis (RARS-T).
Although the multilineage differentiation of AMSCs was successful in vitro, there are many technical challenges on utilizing AMSCs in clinical application for therapeutic purposes, such as high rate of reduction and instability.
"With multilineage cells, we have to start wondering if their final fate is being determined by some selective force or interaction with the environment, rather than just genetic programs," Kirschner said.
Multilineage cells from human adipose tissue: Implications for cell-based therapies.
In these studies, a high KIT D816V allele burden was associated with multilineage involvement, advanced mastocytosis, and poor outcome (14-17).
14 patients had refractory anemia (RA), six had an isolated deletion of the long arm of chromosome 5 (del(5q)), 5 had refractory anemia with ring sideroblasts (RARS), 17 had refractory cytopenia with multilineage dysplasia (RCMD), 15 had refractory anemia with excess blasts 1 (RAEB-1), and 19 had RAEB-2.
These patients experience complications related to uni- or multilineage peripheral cytopenias.

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