(2,3) Research into the aetiology of keratoconus shows that it is likely to be a multifactorial, multigenic disorder
with complex inheritance patterns.
INTRODUCTION: Beckwith-Wiedemann Syndrome (BWS) is an overgrowth, multigenic disorder
caused by dysregulation of the expression of imprinted genes in the 11p15 chromosomal region!11' 12] It is characterized by Omphalocele.
"Our results indicate that the homogeneity of strong genetic risk factors within dog breeds allows multigenic disorders
to be mapped with fewer than 100 cases and 100 controls, making dogs an excellent model in which to identify pathways involved in human complex diseases", said Professor Hannes Lohi, University of Helsinki and Folkhalsan Research Center, Finland.