A 1 standard deviation higher lipoprotein(a) concentration (= 310 mg/L) was associated with a multifactorially adjusted hazard ratio for risk of major bleeding in the brain and airways of 0.96 (95%CI: 0.94-0.98) (Fig.
Multifactorially adjusted hazard ratios and 95% confidence interval for bleeding in brain and airways by increasing Caption: levels of INR.
Multifactorially adjusted hazard ratios with 95% confidence intervals for bleeding in brain and airways.
A doubling in plasma YKL-40 concentrations was associated with multifactorially adjusted increases for alanine aminotransferase of 4.2%, bilirubin of 2.5%, alkaline phosphatase of 5.0%, [gamma]-glutamyl transferase of 16%, erythrocyte mean corpuscular volume of 0.5%, CRP of 19%, and fibrinogen of 0.9% and with decreases for albumin of 0.7%, coagulation factors II, VII, and X of 0.9%, and pancreatic amylase of 1.4% (see online Supplemental Fig.
A doubling in YKL-40 concentration was associated with a multifactorially adjusted observational HR of 2.8 (2.4-3.3) for alcoholic liver cirrhosis and a corresponding OR for a genetic doubling in YKL-40 concentrations of 1.1 (0.7-1.5).
Multifactorially adjusted model included adjustments for age, sex, alcohol consumption, smoking, body mass index, education, and study population.
On the basis of a frequency of ferritin [greater than or equal to]200 [micro]g/L of 16% overall, 26% in men, and 6% in women, and on multifactorially adjusted HRs of 1.1, 1.1, and 1.2, respectively, for total mortality, the corresponding population attributable risks for total mortality were 2% overall, 3% in men, and 1% in women.
Multifactorially adjusted HRs for individuals with ferritin [greater than or equal to]200 vs <200 [micro]g/L were 1.2 (95% CI 1.1-1.3; P = 0.005) for cancer mortality, 1.4 (1.1-1.8; P = 0.002) for endocrinological mortality, and 1.2 (1.1-1.3; P = 0.00006) for cardiovascular mortality (Fig.
On the basis of a frequency of TS [greater than or equal to] 50% of 1.9% overall, 2.8% in men, and 1.1% in women in the 2 studies combined, and on multifactorially
adjusted hazard ratios of 1.4, 1.3, and 1.5, respectively, for total mortality, the corresponding population-attributable risks were 0.8% overall, 0.8% in men, and 0.6% in women.
Risk of early death was increased by 10% [hazard ratios were multifactorially adjusted for sex, age (deciles), and smoking habits (never/previous/current smokers), body mass index, alcohol consumption, plasma cholesterol, systolic blood pressure, physical activity, CRP, and earlier diseases at the time of blood sampling] in participants with cardiovascular disease for plasma YKL-40 concentrations in category 34%-66%, by 20% for 67%-90%, by 80% for 91%-95%, and by 60% for 96%-100% vs YKL-40 category 0%-33% (trend, P < 0.0001).
The corresponding multifactorially adjusted hazard ratio for early death was 1.7 (1.4-2.1).