Willemse et al., "Diminished expression of multidrug resistance-associated protein 1 (MRP1) in bronchial epithelium of COPD patients," Virchows Archiv, vol.
Wang et al., "Upregulation of multidrug resistance-associated protein 1 by allyl isothiocyanate in human bronchial epithelial cell: involvement of cJun N-terminal kinase signaling pathway," Oxidative Medicine and Cellular Longevity, vol.
It was reported that plant-derived polyphenolic compounds, mainly flavonoids and stilbenes or their synthetic derivatives, can modulate the main ABC transporters responsible for cancer drug resistance, including P-gp, multidrug resistance-associated protein 1
(MRP1), and breast cancer resistance protein (BCRP) .
The most commonly observed mechanism contributing to MDR is the overexpression of ABC transporters mainly including P-gp, breast cancer resistant protein (BCRP) and multidrug resistance-associated protein 1
(MRP1) in cancer cells (Fenner et al., 2009).
Homolya, "Portrait of multifaceted transporter, the multidrug resistance-associated protein 1
(MRP1/ABCC1)," Pflugers Archiv-European Journal of Physiology, vol.
Ozben, "Multidrug resistance-associated protein 1
(MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine sulfoximine," Cancer Cell International, vol.
Abbreviations AITC: Allyl isothiocyanate MRP1: Multidrug resistance-associated protein 1 ARE: Antioxidant response elements RT-PCR: Real-time polymerase chain reaction.
Sugiyama, "Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts," Biochemical and Biophysical Research Communications, vol.