ABCC1

(redirected from multidrug resistance-associated protein 1)

ABCC1

A gene on 16p13.1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC1 is a transporter of multispecific organic anions, glucuronides and sulfate conjugates of steroid hormones and bile salts; it mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, methotrexate, antivirals and other xenobiotics, and confers resistance to anticancer drugs.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Willemse et al., "Diminished expression of multidrug resistance-associated protein 1 (MRP1) in bronchial epithelium of COPD patients," Virchows Archiv, vol.
Wang et al., "Upregulation of multidrug resistance-associated protein 1 by allyl isothiocyanate in human bronchial epithelial cell: involvement of cJun N-terminal kinase signaling pathway," Oxidative Medicine and Cellular Longevity, vol.
It was reported that plant-derived polyphenolic compounds, mainly flavonoids and stilbenes or their synthetic derivatives, can modulate the main ABC transporters responsible for cancer drug resistance, including P-gp, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP) [18].
The most commonly observed mechanism contributing to MDR is the overexpression of ABC transporters mainly including P-gp, breast cancer resistant protein (BCRP) and multidrug resistance-associated protein 1 (MRP1) in cancer cells (Fenner et al., 2009).
Homolya, "Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1)," Pflugers Archiv-European Journal of Physiology, vol.
Ozben, "Multidrug resistance-associated protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine sulfoximine," Cancer Cell International, vol.
Abbreviations AITC: Allyl isothiocyanate MRP1: Multidrug resistance-associated protein 1 ARE: Antioxidant response elements RT-PCR: Real-time polymerase chain reaction.
Sugiyama, "Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts," Biochemical and Biophysical Research Communications, vol.
Full browser ?