ABCC3

(redirected from multidrug resistance-associated protein)

ABCC3

A gene on chromosome 17q22 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC3 is thought to play a role in the transport of biliary and intestinal excretion of organic anions.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum.
A marked decrease in multidrug resistance-associated protein 2, an ATP-dependent transporter involved in the bile- and salt-independent bile export system, under oxidative stress caused by lipopolysaccharide (LPS) endotoxins from bacterial outer membrane, has been reported [15-17].
Chang, "A molecular understanding of ATP-dependent solute transport by multidrug resistance-associated protein MRP1," Cancer Metastasis Reviews, vol.
Hofmann, "Primary structure of a novel ABC transporter with a chromosomal localization on the band encoding the multidrug resistance-associated protein," FEBS Letters, vol.
Vore, "Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition," The Journal of Pharmacology and Experimental Therapeutics, vol.
It was reported that plant-derived polyphenolic compounds, mainly flavonoids and stilbenes or their synthetic derivatives, can modulate the main ABC transporters responsible for cancer drug resistance, including P-gp, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP) [18].
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein l.
Multidrug resistance-associated protein 2 is involved in the efflux of aconitum alkaloids determined by MRP2-MDCKI1 cells.
Oh, "Autophagy involvement in cadmium resistance through induction of multidrug resistance-associated protein and counterbalance of endoplasmic reticulum stress WI38 lung epithelial fibroblast cells," Toxicology, vol.
Dubois, " Study of monoglutathionyl conjugates TC-99M-sestamibi and TC-99M-tetrofosmin transport mediated by the multidrug resistance-associated protein isoform 1 in glioma cells," Cancer Biotherapy & Radiopharmaceuticals, vol.
Jiang et al., "Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione," Journal of Biological Chemistry, vol.
Relationship between maj or vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression and drug resistance in childhood leukemia.
Full browser ?