multidrug resistance


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resistance

 [re-zis´tans]
1. opposition, or counteracting force, as opposition of a conductor to passage of electricity or other energy or substance.
2. the natural ability of a normal organism to remain unaffected by noxious agents in its environment; see also immunity.
3. in psychology or psychiatry, conscious or unconscious defenses against change, preventing repressed material from coming into awareness; they can take such forms as forgetfulness, evasions, embarrassment, mental blocks, denial, anger, superficial talk, intellectualization, or intensification of symptoms. It occurs because the blocked association or understanding would be too threatening to face at this point in the therapy; identification of what point the resistance comes at can be an important indicator of the patient's unconscious patterns.
airway resistance the opposition of the tissues of the air passages to air flow: the mouth-to-alveoli pressure difference divided by the rate of air flow. Symbol RA or RAW.
androgen resistance resistance of target organs to the action of androgens, resulting in any of a spectrum of defects from a normal male phenotype in which men have normal genitalia but infertility to complete androgen resistance in which the individual has a female phenotype. Complete androgen resistance is an extreme form of male pseudohermaphroditism in which the individual is phenotypically female but is of XY chromosomal sex; there may be rudimentary uterus and tubes, but the gonads are typically testes, which may be abdominal or inguinal in position. Called also testicular feminization and testicular feminization syndrome. Incomplete androgen resistance is any of various forms less than the complete type, manifested by a male phenotype with various degrees of ambiguous genitalia such as hypospadias and a small vaginal pouch, a hooded phallus, or a bifid scrotum that may or may not contain gonads.
drug resistance the ability of a microorganism to withstand the effects of a drug that are lethal to most members of its species.
insulin resistance see insulin resistance.
multidrug resistance (multiple drug resistance) a phenomenon seen in some malignant cell lines: cells that have developed natural resistance to a single cytotoxic compound are also resistant to structurally unrelated chemotherapy agents. Called also cross-resistance.
peripheral resistance resistance to the passage of blood through the small blood vessels, especially the arterioles.
pulmonary vascular resistance the vascular resistance of the pulmonary circulation; the difference between the mean pulmonary arterial pressure and the left atrial filling pressure divided by the cardiac output. Called also total pulmonary vascular resistance.
total peripheral resistance the vascular resistance of the systemic circulation: the difference between the mean arterial pressure and central venous pressure divided by the cardiac output.
total pulmonary resistance (total pulmonary vascular resistance) pulmonary vascular resistance.
vascular resistance the opposition to blood flow in a vascular bed; the pressure drop across the bed divided by the blood flow, conventionally expressed in peripheral resistance units. Symbol R or R.

mul·ti·drug re·sis·tance (MDR),

the insensitivity of various tumors to a variety of chemically related anticancer drugs; mediated by a process of inactivating the drug or removing it from the target tumor cells.
References in periodicals archive ?
A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. Cancer Res.
The highest rate of multidrug resistance was observed with GroupC 26 (31.52%) isolates, in which this isolate was able to resist all Quinolones and Fluroquinolones antimicrobial agents.as well as Group B distinguished in 11(11.96%) isolates.
Our study also identified certain risk factors, which were found to be significantly associated and need to be taken care of to prevent multidrug resistance. Wise and effective use of antibiotics, effective surveillance of resistance and adherence to infection control practices, perhaps are the key factors that may prevent the development and spread of multidrug resistance among the prevalent strains of acinetobacter species.
The 1128 DEGs are involved in 122 KEGG pathways (Figure 2) wherein bacterial chemotaxis, ABC transporter, and [beta]-lactam resistance may be associated with multidrug resistance in the MDR isolate strain of C.
The ability of SSE15206 to overcome multidrug resistance makes this class of molecules promising precursors for developing drugs that can do the same, he elaborated
falciparum multidrug resistance protein 1 (pfmrpl) gene that encodes the PfMRP1 protein is a member of the ABC transporter superfamily located on chromosome 1 [19].
Schneiders, "Elucidating the regulon of multidrug resistance regulator RarA in Klebsiella pneumoniae," Antimicrobial Agents and Chemotherapy, vol.
Agarwal, "Multidrug resistance protein-1 expression function and polymorphisms in patients with rheumatoid arthritis not responding to methotrexate," International Journal of Rheumatic Diseases, vol.
Emergence of Multidrug Resistance and Metallo-beta-lactamase Producing Acinetobacter baumannii Isolated from Patients in Shiraz, Iran.
This interface region seems to be a hot-spot for structural stability, proper folding, and assembly of different ABC transporters including CFTR (ABCC7) and multidrug resistance proteins (MRPs) and furthermore a location enriched in disease-causing mutations [6,18,25,26].
The data of this study suggests that multidrug resistance may be widespread among enteric bacterial organisms in Ghana.
Subfamilies of multidrug resistance proteins (MDRs and ABCB), multidrug resistance-associated proteins (MRPs and ABCC), and breast cancer resistance protein (BCRP and ABCG2) also belongto the human ABC transporter family [5].

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