multicystic kidney


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pol·y·cys·tic kid·ney

a progressive disease characterized by formation of multiple cysts of varying size scattered diffusely throughout both kidneys, resulting in compression and destruction of renal parenchyma, usually with hypertension, gross hematuria, and uremia leading to progressive renal failure. There are two major types: with onset in infancy or early childhood, usually of autosomal recessive inheritance [MIM*263200]; with onset in adulthood, of autosomal dominant inheritance with genetic heterogeneity [MIM*173900, 173910, and 600666]; may be caused by mutation in either polycystin-1 gene on chromosome 16p, polycystin-2 gene on 4q, or gene(s) not identified yet.

multicystic kidney

see Polycystic kidney.
References in periodicals archive ?
Coccygeal polypoid eccrine nevus associated with imperforate anus and unilateral multicystic kidney dysplasia.
Multicystic kidney disease (MCKD) is a developmental disorder of the kidney, in which the normal renal parenchyma is replaced by multiple, non-communicating cysts of varying size.
Bilateral multicystic kidney disease occurs in about 10-20% of cases and is a lethal condition.
It is worth noting that the often-quoted rate of vesicoureteral reflux up to 43% from the Multicystic Kidney Registry is prone to selection bias as only 15% of patients in the registry had a voiding cystogram.[sup.30]
Risk of Wilms' tumour with multicystic kidney disease: a systematic review.
Risk of hypertension with multicystic kidney disease: a systematic review.
Risk ofWilms' tumour with multicystic kidney disease: a systematic review.
In particular, genitourinary malformations such as dysplastic and multicystic kidneys, hydronephrosis, hydroureter, ureterocele, duplicated renal collecting system, and absent bladder are common as extensive injury and fibrosis of the uroepithelium can lead to obstructive uropathies [15].
Other conditions that may be associated with DiGeorge are atopic disorders (asthma and eczema) rheumatoid arthritis, autoimmune thyroiditis, renal abnormalities (such as multicystic kidneys and Vesicoureteral reflux).
Table 2: Type of Anomaly (n=62) Type of Anomaly Frequency Hydrocephalus 16 Anencephaly 14 Meningomyelocele 4 Encephalocele 6 CNS Anomalies, [49 (79%)] Hydroceph+meningomylocele 4 Anenceph+spinabifida 2Isolated Microcephalous 1Anomalies, [57(91.9%)] Acrania 1 Dandy walker malformation 1 Polyscystic kidneys 2 Renal Anomalies, [4 (6.5%)] Dysplastic Multicystic kidneys 2 Omphalocele 1 GIT Anomalies, [2 (3.2%)] Gastroschisis 1 Skeletal Anomalies, [2 (3.2%)] Achondroplasia 2 Mickel Gruber syndrome 2 Hydroceph, Omphalocele 1Complex Anomalies, [5 (8.1%)] Esophageal atresia, Renal anomlies 1 Facial abnormalities, Talipes, Esophageal 1 atresia, Renal agenesis
The findings included large multicystic kidneys bilaterally.
For example, multicystic kidneys erroneously called MCDKs were proven to be examples of GCKD instead.