Torg-Winchester syndrome
(redirected from multicentric osteolysis with nodulosis and arthropathy)Torg-Winchester syndrome
An autosomal recessive syndrome (OMIM:259600) characterised by generalised osteolysis and osteopenia, coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gingival hypertrophy.Molecular pathology
TWS is caused by mutation of MMP2 on chromosome 16q13-q21, which encodes matrix metalloproteinase 2.