Papillary carcinoma can be unifocal, multifocal or multicentric
. In present study single nodular lesions were identified in 12 cases (27.2%), more than one lesion in the same lobe (multifocal) in 11 cases (25%) and focal lesions in both lobes (multicentric
) in 7 cases (15.9%).
This virus is also held responsible for the development of primary effusion lymphoma and multicentric
Middleton et al (15) observed identical ER/PR/HER2 staining pattern in 14 of 32 multicentric
cases (44%), in which additional tumor foci were also tested for biomarkers.
Four subtypes of CD are described: (1) hyaline vascular--usually unicentric, (2) plasma cell rich--more frequently multicentric
(3) HHV-8 associated CD--mainly multicentric
in the immunocompromised and (4) multicentric
not otherwise specified .
Since more cats are being tested and isolated if positive or vaccinated if negative, the incidence of mediastinal and multicentric
lymphomas in cats has decreased, but intestinal lymphomas have picked up.
Multifocal hepatocellular carcinoma: Intrahepatic metastasis or multicentric
Six years of R&D with 12 $millions invested, including the last largest clinical multicentric
trial never ever made, NEWROFEED-Koala, successfuly lead to the grant of a CE mark class IIa in Europe.
It has been reported that multicentric
smooth muscle tumors arising from vaginal wall and cervix can be invasive and may result in considerable haemorrhages and death in goats (Cooper and Valentine, 2002; Uzal and Puscher, 2008).
carpotarsal osteolysis syndrome (MCTO, OMIM # 166300), also called idiopathic multicentric
osteolysis with progressive nephropathy, is a rare autosomal dominant disorder characterized by progressive osteolysis, predominantly of the carpal and tarsal bones.
CD can be unicentric (U-CD), usually restricted to the mediastinum, or multicentric
(M-CD): the first is typically identified incidentally or though symptoms from the local mass effect; the latter form is more symptomatic, including fever, night sweats, weight loss, and anorexia.
It can be unicentric or multicentric
. HHV8 related clinical manifestations range from Kaposi Sarcoma (KS), intracavity primary effusion lymphoma (PEL) and systemic multicentric
Castleman disease (MCD).