In addition, mucosal immunization
possesses a number of advantages, including ease of administration and reduced risks of infection by contaminated injection devices.
with Surface-Displayed Severe Acute Respiratory Syndrome Coronavirus Spike Protein on Lactobacillus casei Induces Neutralizing Antibodies in Mice.
They published a paper in the journal "Vaccine," and I can tell you that after reading that study ("Mucosal immunization
with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease"), the research was difficult, detailed, very technical, and not the easiest reading for a layperson, or someone without a medical, science-based background.
The results showed that mIL-33 as a molecular adjuvant for pcDLzp3 DNA vaccine could enhance systemic Ab responses against ZP3 through mucosal immunization
LePage, "Mucosal immunization
with recombinant Lactococcus lactis'" in Gram-Positive Bacteria as Vaccine Vehicles for Mucosal Immunization
with a subunit respiratory syncytial virus vaccine in mice.
(30) reported that mucosal immunization
of African green monkeys with an attenuated parainfluenza virus expressing S protein resulted in production of neutralizing antibodies and protected animals from infection by challenge with SARS-CoV.
Therefore, chimeric HA-containing VLPs represent a potential approach for mucosal immunization
for prevention of HIV infection.
Most importantly, mucosal immunization
elicits antigen-specific local IgA and systemic IgG antibodies, as well as strong systemic and tissue resident [CD4.sup.+] and [CD8.sup.+] T cell immunity (Figure 1).
Modified polio virus vector--Genetically engineered poliovirus offers many attractive features for development as a vaccine vector for mucosal immunization
. Poliovirus is transmitted orally and enters immunoreactive mucosal sites.
with PspA can also elicit immunity to carriage (11,12).
Majority of previous studies seek to induce mucosal immune responses by mucosal immunization
[8-11]; however, this may not be applicable for naked DNA vaccines due to the relative weak immunogenicity .