MADCAM1

(redirected from mucosal addressin cell adhesion molecule-1)

MADCAM1

A gene located on chromosome 19q13.3 that encodes a protein belonging to the immunoglobulin superfamily, which is an endothelial cell-adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1, L-selectin and VLA-4 on myeloid cells to direct leukocytes into mucosal tissue (e.g., into Peyer patches and intestinal lamina propria) and into inflamed tissues.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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References in periodicals archive ?
SHP647 is a fully human IgG2 monoclonal antibody that targets the mucosal addressin cell adhesion molecule-1 (MAdCAM-1).
Forty-eight hours postoperation, tissue samples were excised from the terminal ileum for immunohistochemical evaluation of the expression of [CD68.sup.+] macrophages, [CD4.sup.+] T-lymphocytes, [CD8.sup.+] T-lymphocytes, the mucosal addressin cell adhesion molecule-1 (MAdCAM-1), interleukin-6 (IL-6), tumor necrosis factor-[alpha] (TNF[alpha]), and nuclear factor-[kappa]B (NF[kappa]B).
Suzuki et al., "Differential expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in ulcerative colitis and Crohn's disease," Pathology International, vol.