The data demonstrate that inhaled RPL554 activates CFTR, and stimulates an increase in ciliary beat frequency, thus having the potential to increase mucociliary
clearance and as a consequence the ability to help to reinstate a central function impaired in this disease.
Accordingly, the current study aimed to explore the efficacy of EPs[R] 7630 in an infective bronchitis animal model, and on common symptoms associated with airways infection, cough and mucociliary
This case showed the spontaneous movement of a foreign body to the natural ostium of the maxillary sinus with the aid of mucociliary
Spyryx is developing inhaled peptides, which are designed to potently degrade ENaC, blocking this absorption and returning airway fluid volumes to normal levels, with the goal of restoring proper mucociliary
It modulates mucus production and viscosity and increases the motility of the mucociliary
transport, improving expectoration.
The serpentine chrysotiles, because of their coiled, pliable nature, appear to impact more in the upper respiratory tract where they can be evacuated from the body via the mucociliary
Following the completion of the Phase 1 safety and tolerability study in CF patients, Pulmatrix plans to begin a Phase 1b clinical trial of PUR118 in CF patients evaluating mucociliary
clearance velocity as an endpoint.
the expulsive effects of the mucociliary
escalator in the airways
In cellular and animal models brevenal appears far more potent than existing drugs for CF and COPD and exhibits the unique quality of both suppressing inflammation and boosting mucociliary
Abnormal ion transport and defective mucociliary
clearance are fundamental defects that contribute to complications of CF lung disease, including mucus plugging, chronic bacterial infection, inflammation and progressive airway damage," Accurso noted.
Miller continued, "Previous preclinical and exploratory clinical studies suggest that surfactant may improve mucociliary
clearance, thereby potentially preventing further compromise of lung function.
Secondary to a failure in mucociliary
defense mechanisms, recurrent pulmonary infections often leads to bronchiectasis seen in PCD patients.